Fe(Ⅲ)-juglone nanoscale coordination polymers for cascade chemodynamic therapy through synergistic ferroptosis and apoptosis strategy  

作　　者：Zhendong Liu Sainan Liu Bin Liu Qi Meng Meng Yuan Chunzheng Yang Yulong Bian Ping'an Ma Jun Lin 

机构地区：[1]State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [2]School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China [3]College of Materials Science and Chemical Engineering,Harbin Engineering University,Harbin 150001,China

出　　处：《Chinese Chemical Letters》2024年第11期413-418,共6页中国化学快报（英文版）

基　　金：financially supported by the National Key Research and Development Program of China(No.2022YFB3503700);the National Natural Science Foundation of China(NSFC,Nos.51929201,52102354,and 52202353);the projects for science and technology development plan of Jilin province(Nos.20220101070JC,20210402046GH,and 20220508089RC)。

摘　　要：Chemodynamic therapy(CDT)relying on the transformation of endogenous hydrogen peroxide(H_(2)O_(2))into cytotoxic hydroxyl radicals(·OH)based on the catalysis of Fenton/Fenton-type reactions exhibits great potentiality for cancer treatment.However,the inadequate H_(2)O_(2)supply and intricate redox homeostasis in tumor microenvironment(TME)severely impair the efficacy of CDT.Herein,we design selfassembled 1,2-distearoyl-sn-glycero-3-phosphoethanolamine conjugated polyethylene glycol(DSPE-PEG)-modified Fe(Ⅲ)-juglone nanoscale coordination polymers(FJP NCPs)as redox homeostasis disruptors for juglone-enhanced CDT.Responding to glutathione(GSH)-rich and acidic TME,the Fe^(2+)/Fe^(3+)-guided CDT and GSH consumption by Fe^(3+)are activated,resulting in·OH downstream and up-regulation of lipid peroxidation(LPO).In addition,the released juglone not only depletes GSH through Michael addition,but also elevates intracellular H_(2)O_(2)level for achieving·OH further bursting.With the impressive efficiency of GSH exhaustion and reactive oxygen species(ROS)storm generation,ferroptosis and apoptosis are significantly enhanced by FJP NCPs in vivo.In brief,this facile and efficient design for versatile nanoscale coordination polymers presents a novel paradigm for effectively elevating CDT efficiency and tumor synergistic therapy.

关 键 词：Nanoscale coordination polymers JUGLONE Tumor microenvironment Enhanced chemodynamic therapy Ferroptosis 

分 类 号：TQ317[化学工程—高聚物工业] TB383.1[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]