JUGLONE

作品数:17被引量:50H指数:4
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相关作者:李玲董子明连鸿凯陈平马俊芬更多>>
相关机构:华中科技大学郑州市骨科医院郑州大学广东医学院更多>>
相关期刊:《Journal of Beijing Institute of Technology》《世界华人消化杂志》《华中科技大学学报(医学版)》《Chinese Journal of Integrative Medicine》更多>>
相关基金:国家自然科学基金更多>>
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Fe(Ⅲ)-juglone nanoscale coordination polymers for cascade chemodynamic therapy through synergistic ferroptosis and apoptosis strategy
《Chinese Chemical Letters》2024年第11期413-418,共6页Zhendong Liu Sainan Liu Bin Liu Qi Meng Meng Yuan Chunzheng Yang Yulong Bian Ping'an Ma Jun Lin 
financially supported by the National Key Research and Development Program of China(No.2022YFB3503700);the National Natural Science Foundation of China(NSFC,Nos.51929201,52102354,and 52202353);the projects for science and technology development plan of Jilin province(Nos.20220101070JC,20210402046GH,and 20220508089RC)。
Chemodynamic therapy(CDT)relying on the transformation of endogenous hydrogen peroxide(H_(2)O_(2))into cytotoxic hydroxyl radicals(·OH)based on the catalysis of Fenton/Fenton-type reactions exhibits great potentialit...
关键词:Nanoscale coordination polymers JUGLONE Tumor microenvironment Enhanced chemodynamic therapy Ferroptosis 
Effects of walnut(Juglans regia L.)kernel extract and juglone on dopamine levels and oxidative stress in rats
《Food Bioscience》2023年第1期906-913,共8页Sener Cintesun Zeynep Ozman Abdurrahim Kocyigit Banu Mansuroglu Ismail Kocacaliskan 
3,4-dihydroxyphenethylamine(dopamine)is a neurotransmitter that has vital functions in the nervous system.Dopamine metabolism and reactive oxygen species(ROS)production are highly related processes.The present study a...
关键词:DOPAMINE WALNUT JUGLONE Total antioxidant status Total oxidant status Oxidative stress 
2-Methoxyjuglone, a Promising Bioactive Compound for Pharmaceutical and Agricultural Purposes: A Review
《Current Medical Science》2022年第5期905-912,共8页Heng-yi YU Lin LIU Juan LI Dong LIU Han-li RUAN 
supported by the National Natural Science Foundation of China(No.21572073 and No.3150010539).
2-Methoxyjuglone,a member of the 1,4-naphthoquinone family,was first obtained through semi-synthesis based on 2-hydroxyjuglone as the precursor in 1966.It has been isolated and identified from different plant species ...
关键词:2-methoxyjuglone BIOACTIVITIES plant sources synthesis REVIEW 
Jug-PLGA-NPs, a New Form of Juglone with Enhanced Efficiency and Reduced Toxicity on Melanoma
《Chinese Journal of Integrative Medicine》2022年第10期909-917,共9页YUE Wu-heng QIN Lan-qun CAI Juan MEI Rui QIAN Han-qing ZOU Zheng-yun 
Supported by the National Natural Science Foundation of China (Nos.81872484 and 82073365);the Social Development Fund of Jiangsu Province,China (No.BE2019605)。
Objective: To verrify the anti-tumor efficacy and toxicity between juglone(Jug) and Jug-loaded poly lactic-co-glycolic acid(PLGA) nanoparticles(Jug-PLGA-NPs). Methods: Jug-PLGA-NPs were prepared by ultrasonic emulsifi...
关键词:JUGLONE PLGA nanoparticles malignant melanoma Jug-PLGA-NPs 
The origin and biosynthesis of the naphthalenoid moiety of juglone in black walnut
《Horticulture Research》2018年第1期159-169,共11页Rachel M.McCoy Sagar M.Utturkar Joseph W.Crook Jyothi Thimmapuram Joshua R.Widhalm 
This work was supported by start-up funds and a Showalter Trust Fund award for bioinformatics support from Purdue University to J.R.W;This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. DGE-1333468 to J.W.C. We thank Jim McKenna (Hardwood Tree Improvement and Regeneration Center, Purdue University) for providing black walnut seedlings and collecting tissues from mature trees, Elena Yakubova for technical assistance, and Jing Yuan for assistance with microscopy.
Several members of the Juglandaceae family produce juglone,a specialized 1,4-naphthoquinone(1,4-NQ)natural product that is responsible for the notorious allelopathic effects of black walnut(Juglans nigra).Despite its ...
关键词:MOIETY ROOTS synthesizing 
Experimental study on the apoptosis of cervical cancer Hela cells induced by juglone through c-Jun N-terminal kinase/c-Jun pathway被引量:16
《Asian Pacific Journal of Tropical Medicine》2017年第6期641-644,共4页Zhai Lu Hua Chen Xiao-Mei Zheng Man-Ling Chen 
supported by the Hainan Health Department(2002lx-12)
Objective: To study the regulatory effect and molecular mechanism of juglone on apoptosis of cervical cancer Hela cells. Methods: Cervical cancer Hela cells were cultured and treated with different dosages of juglone ...
关键词:Cervical cancer JUGLONE c-Jun N-terminal kinase APOPTOSIS MITOCHONDRIA Death receptor 
Effect of Pin1 Inhibitor Juglone on Proliferation,Migration and Angiogenic Ability of Breast Cancer Cell Line MCF7Adr被引量:4
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2015年第4期531-534,共4页胡远贵 沈云峰 李毅 
Summary: This study aimed to evaluate the effects of Pinl inhibitor Juglone on proliferation, migration and the angiogenic ability of breast cancer cell line MCF7Adr. MCF7Adr ceils were cultured and sepa- rately trea...
关键词:breast cancer Pin1 inhibitor cell cycle ANGIOGENESIS 
Effect of juglone on immunity response and oxidative stress in mice
《Journal of Beijing Institute of Technology》2015年第1期139-142,共4页李岩 董继锐 马晓科 冯会红 陈晓 赵剑璞 郭楠 刘品多 
To research juglone's immunology regulation, several perspectives including immunology regulation, lymphocyte proliferation, and cytokines were presented. The index of thymus and spleen, total supperoxide dismutase a...
关键词:JUGLONE IMMUNITY oxidative stress MICE 
Juglone对人鼻咽癌细胞株CNE-2Z细胞增殖及细胞周期的抑制作用被引量:5
《山东医药》2012年第16期7-8,11,共3页崔平 李蓉 刘英霞 蔡康荣 何志巍 
国家自然科学基金资助项目(30973374)
目的测定Pin1抑制剂(Juglone)对人鼻咽癌细胞株CNE-2Z细胞生长增殖及细胞周期的影响,讨论Ju-glone的抗鼻咽癌肿瘤的作用效果。方法体外培养人鼻咽癌CNE-2Z细胞,采用MTT实验观察细胞生长增殖状况,流式细胞仪检测细胞周期。结果 MTT测定...
关键词:JUGLONE 细胞增殖 细胞周期 鼻咽肿瘤 
Synthesis and Antibacterial Activity of Juglone Derivatives被引量:1
《Journal of Chemistry and Chemical Engineering》2012年第1期84-89,共6页Daniel Teoh Chuan Tan Hasnah Osman Suriyati Mohamad Azlina Harun Kamaruddin 
Nitro and halogen substituted derivatives of the juglone naphthoquinone were synthesized and assayed for their antibacterial activity. 8-Nitrojuglone was obtained as the exclusive product from the direct nitration of ...
关键词:NAPHTHOQUINONE NITRATION Friedel-Crafts acylation ANTHRAQUINONE antibacterial activity. 
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