financially supported by the National Key Research and Development Program of China(No.2022YFB3503700);the National Natural Science Foundation of China(NSFC,Nos.51929201,52102354,and 52202353);the projects for science and technology development plan of Jilin province(Nos.20220101070JC,20210402046GH,and 20220508089RC)。
Chemodynamic therapy(CDT)relying on the transformation of endogenous hydrogen peroxide(H_(2)O_(2))into cytotoxic hydroxyl radicals(·OH)based on the catalysis of Fenton/Fenton-type reactions exhibits great potentialit...
3,4-dihydroxyphenethylamine(dopamine)is a neurotransmitter that has vital functions in the nervous system.Dopamine metabolism and reactive oxygen species(ROS)production are highly related processes.The present study a...
supported by the National Natural Science Foundation of China(No.21572073 and No.3150010539).
2-Methoxyjuglone,a member of the 1,4-naphthoquinone family,was first obtained through semi-synthesis based on 2-hydroxyjuglone as the precursor in 1966.It has been isolated and identified from different plant species ...
Supported by the National Natural Science Foundation of China (Nos.81872484 and 82073365);the Social Development Fund of Jiangsu Province,China (No.BE2019605)。
Objective: To verrify the anti-tumor efficacy and toxicity between juglone(Jug) and Jug-loaded poly lactic-co-glycolic acid(PLGA) nanoparticles(Jug-PLGA-NPs). Methods: Jug-PLGA-NPs were prepared by ultrasonic emulsifi...
This work was supported by start-up funds and a Showalter Trust Fund award for bioinformatics support from Purdue University to J.R.W;This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. DGE-1333468 to J.W.C. We thank Jim McKenna (Hardwood Tree Improvement and Regeneration Center, Purdue University) for providing black walnut seedlings and collecting tissues from mature trees, Elena Yakubova for technical assistance, and Jing Yuan for assistance with microscopy.
Several members of the Juglandaceae family produce juglone,a specialized 1,4-naphthoquinone(1,4-NQ)natural product that is responsible for the notorious allelopathic effects of black walnut(Juglans nigra).Despite its ...
supported by the Hainan Health Department(2002lx-12)
Objective: To study the regulatory effect and molecular mechanism of juglone on apoptosis of cervical cancer Hela cells. Methods: Cervical cancer Hela cells were cultured and treated with different dosages of juglone ...
Summary: This study aimed to evaluate the effects of Pinl inhibitor Juglone on proliferation, migration and the angiogenic ability of breast cancer cell line MCF7Adr. MCF7Adr ceils were cultured and sepa- rately trea...
To research juglone's immunology regulation, several perspectives including immunology regulation, lymphocyte proliferation, and cytokines were presented. The index of thymus and spleen, total supperoxide dismutase a...
Nitro and halogen substituted derivatives of the juglone naphthoquinone were synthesized and assayed for their antibacterial activity. 8-Nitrojuglone was obtained as the exclusive product from the direct nitration of ...