Personalized precision radiotherapy and its evolving role for human papillomavirus-positive oropharyngeal cancer  

作　　者：Hayden Ansinelli Chris Gay Steven Nguyen Christopher M.Morrison Jared R.Robbins 

机构地区：[1]University of Arizona College of Medicine,Department of Radiation Oncology,Tucson,United States

出　　处：《Journal of the National Cancer Center》2023年第1期72-82,共11页癌症科学进展（英文）

摘　　要：Human papilloma virus(HPV)-associated oropharyngeal cancer(OPC)is a unique entity with increased respon-siveness to treatment and excellent oncologic outcomes.The purpose of this narrative review is to highlight how an improved prognosis for HPV(+)tumors and an ever-increasing understanding of the risk factors,risk stratification,and areas of potential spread are shaping management options.Additionally,we aim to detail how advances in treatment technology on both the surgical and radiation fronts are facilitating the delivery of increas-ingly personalized and precise treatments.This review will describe key aspects of recent and currently-ongoing trials investigating the de-escalation and individualization of treatment in this patient cohort,and how they are building a foundation for distinct treatment paradigms for HPV(+)tumors.Further studies into the integration of biomarker-guided treatments combined with clinical trial enrollment will help ensure a future of personalized treatments and improved outcomes,both in terms of oncologic outcomes and toxicity,for patients with HPV(+)OPC.

关 键 词：RADIOTHERAPY DE-ESCALATION Human papillomavirus Oropharyngeal cancer 

分 类 号：R73[医药卫生—肿瘤]