胆盐刺激性脂肪酶功能研究进展  

Research Progress on the Functions of Bile Salt-Stimulated Lipase

作　　者：邹芸霞 孟庆勇[2] 戴蕴平[2] 张雅丽[1] ZOU Yunxia;MENG Qingyong;DAI Yunping;ZHANG Yali(College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083;College of Biological Sciences,China Agricultural University,Beijing 100083)

机构地区：[1]中国农业大学食品科学与营养工程学院,北京100083 [2]中国农业大学生物学院,北京100083

出　　处：《食品与生物技术学报》2024年第8期1-10,共10页Journal of Food Science and Biotechnology

基　　金：农业生物育种国家科技重大专项项目(2023ZD0404905)。

摘　　要：胆盐刺激性脂肪酶(bile salt-stimulated lipase,BSSL)是一种脂肪分解酶。人体中的BSSL主要来自胰腺,也存在于人哺乳期乳腺中,并随乳汁分泌,是含量最丰富的乳清蛋白之一。BSSL能够作用于多种底物,包括甘油三酯(triglyceride,TG)、胆固醇酯、脂溶性维生素、神经酰胺等,对新生儿早期消化吸收乳汁中的脂类物质至关重要。国内外研究发现,BSSL不仅能够促进婴幼儿对乳脂的消化,其在调节血栓、炎症反应、动脉粥样硬化等方面也具有重要功能。作者综述了BSSL的特点及其功能,并对其在婴幼儿配方奶粉中的应用进行了展望。Bile salt-stimulated lipase(BSSL)is a lipolytic enzyme.In the human body,BSSL is primarily secreted by the pancreas and is also found in the mammary glands during lactation,secreted with milk,which is one of the most abundant whey proteins.BSSL can hydrolyze a variety of substrates,including cholesteryl esters,fat-soluble vitamins,ceramide,etc.,and plays a crucial role in the early digestion and absorption of milk lipids by newborns.Recent domestic and international studies have shown that in addition to promoting the digestion of milk fat in infants and young children,BSSL also plays significant roles in pathogen resistance,thrombosis regulation,inflammation modulation,atherosclerosis prevention and so on.The author summarizes the characteristics and functions of BSSL and explores its potential applications in infant formula.

关 键 词：脂肪酶 消化脂肪 乳清蛋白 婴儿 

分 类 号：TS252.51[轻工技术与工程—农产品加工及贮藏工程]