KCNE单核苷酸多态性与心血管疾病及内耳疾病的相关性研究  

Correlation between KCNE single nucleotide polymorphisms and cardiovascular diseases

作　　者：杨咏琪 王丽媛 褚田青 刘好华(综述) 胡斌(审校)[1] YANG Yongqi;WANG Liyuan;CHU Tianqing;LIU Haohua;HU Bin(Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education,Gannan Medical University,Ganzhou,Jiangxi 341000,China;Department of Laboratory,the Second Hospital of Sanming,Sanming,Fujian 366000,China)

机构地区：[1]赣南医科大学心脑血管疾病防治教育部重点实验室,江西赣州341000 [2]福建省三明市第二医院检验科,福建三明366000

出　　处：《检验医学与临床》2024年第23期3576-3580,共5页Laboratory Medicine and Clinic

基　　金：江西省教育厅科学技术研究项目(GJJ2201447)。

摘　　要：KCNE辅助亚基参与调控多种电压门控钾离子通道,对维持机体正常的生理功能十分重要。目前许多研究显示,KCNE家族的单核苷酸多态性(SNP)与心血管疾病和内耳疾病的发生密切相关,但由于其复杂的遗传机制及其易受到地域、种族和个体差异等的影响,还需对KCNE SNP与疾病易感性之间的相关性及遗传规律进行探索,以探讨KCNE SNP作为诊断某些疾病的潜在生物标志物的可能。故该文主要就KCNE SNP与心血管疾病和内耳疾病之间相关性的研究进展进行综述,旨在为疾病的预防及治疗提供理论依据。KCNE auxiliary subunits are involved in the regulation of various voltage-gated potassium channels,which are important for maintaining normal physiological functions of the body.Current studies have shown that single nucleotide polymorphisms(SNP)in the KCNE family are closely related to the occurrence of cardiovascular and inner ear diseases,and due to its complex genetic mechanism and its susceptibility to geographical,racial and individual differences,it is necessary to explore the correlation of KCNE SNPs and susceptibility to diseases with the genetic pattern,in order to explore the possibility that the KCNE SNPs may serve as a potential biomarker for the diagnosis of certain diseases.KCNE SNPs may be potential biomarkers for diagnosing some diseases.This article summarizes the research progress on the correlation of KCNE SNP with cardiovascular diseases and inner ear diseases,aiming to provide a theoretical basis for disease prevention and treatment.

关 键 词：KCNE 单核苷酸多态性 心房颤动 长QT综合征 梅尼埃病 

分 类 号：R394.3[医药卫生—医学遗传学]