Fabrication and comprehensive evaluation of Zr-based bulk metallic glass matrix composites for biomedical applications  

作　　者：Mariusz Hasiak Beata Sobieszczańska Amadeusz Łaszcz Michał Biały Jacek Chęcmanowski Tomasz Zatoński 

机构地区：[1]Department of Mechanics,Materials and Biomedical Engineering,Wrocław University of Science and Technology,Wrocław 50-370,Poland [2]Department of Microbiology,Wrocław Medical University,Wrocław 50-368,Poland [3]Department of Advanced Materials Technologies,Wrocław University of Science and Technology,Wrocław 50-370,Poland [4]Clinical Department of Otolaryngology,Head and Neck Surgery,Wrocław Medical University,Wrocław 50-556,Poland

出　　处：《Science China Materials》2024年第12期4087-4100,共14页中国科学（材料科学）（英文版）

基　　金：Open Access funding provided by Wrocław University of Science and Technology

摘　　要：The aim of this study is to fabricate Zr-based bulk metallic glass matrix composites(BMG-MCs)for biomedical usage and subject them to a comprehensive and farreaching analysis with respect to their mechanical properties,biocorrosion resistance,biocompatibility,and interactions with biofilms that all may arise from their chemical compositions and unusual disordered internal structure.In this study,we fabricate Zr_(40)Ti_(15)Cu_(10)Ni_(10)Be_(25),Zr_(50)Ti_(15)Cu_(10)Ni_(10)Be_(25),and Zr40Ti15Cu10Ni5Si5Be25 alloys and confirm their glassy matrix nature through differential scanning calorimetry(DSC)and scanning electron microscopy(SEM)analyses.The mechanical properties,assessed via nanoindentation,demonstrate the high hardness,strength,and elasticity of the produced materials.Corrosion resistance is investigated in simulated body fluid,with Zr-based BMG-MCs exhibiting superior performance compared to conventional biomedical materials,including 316L stainless steel and Ti6Al4V alloy.Biocompatibility is assessed using human fetal osteoblastic cell line hFOB 1.19,revealing low levels of cytotoxicity.The study also examines the potential for biofilm formation,a critical factor in the success of biomedical implantation,where bacterial infection is a major concern.Our findings suggest,as never reported before,that Zr-based BMG-MCs,with their unique composite glassy structure and excellent physicochemical properties,are promising candidates for various biomedical applications,potentially offering improved performance over traditional metallic biomaterials.

关 键 词：metallic glasses COMPOSITES BIOMATERIALS mechanical property CYTOTOXICITY 

分 类 号：R318.08[医药卫生—生物医学工程] TB33[医药卫生—基础医学]