Rhodium-Catalyzed Asymmetric Hydrogenation of Tetrasubstitutedα,β-Unsaturated Amides:Efficient Access to Chiralβ-Amino Amides  

作　　者：Bing Jiao Fangyuan Wang Hui Lv 

机构地区：[1]State Key Laboratory of Power Grid Environmental Protection/Hubei Key Lab on Organic and Polymeric Optoelectronic Materials/Engineering Research Center of Organosilicon Compounds&Materials,Ministry of Education/Key Laboratory of Biomedical Polymers of Ministry of Education&College of Chemistry and Molecular Sciences,Wuhan University,Wuhan,Hubei,430072 China

出　　处：《Chinese Journal of Chemistry》2024年第21期2641-2646,共6页中国化学（英文版）

基　　金：financial support from the National Natural Science Foundation of China(Grant Nos.22071188,22371217);Hubei Provincial Natural Science Foundation of China(2023AFA011).

摘　　要：The first asymmetric hydrogenation of acyclic tetrasubstitutedα,β-unsaturated amides has been achieved by using Rh/DuanPhos complex as a catalyst,delivering chiralβ-amino amides with two contiguous chiral centers in excellent yields and high enantioselectivities(up to 99%yield,96%ee),which provides efficient and concise access to valuableβ-amino amide derivatives.The gram-scale reaction and efficient transformation ofβ-amino amide toβ-amino acid andβ-amino cyanide demonstrated the utility of this methodology.

关 键 词：Asymmetric hydrogenation β-Amino amides Asymmetric catalysis Contiguous chiral centers RHODIUM AMINES Reduction ENANTIOSELECTIVITY 

分 类 号：O62[理学—有机化学]