微生物发酵在天然α-葡萄糖苷酶抑制剂研究中的应用进展  

Application Progress in Microbial Fermentation Technology in Developing Naturalα-Glucosidase Inhibitors

作　　者：邱卫华[1] 刘瑾如 QIU Weihua;LIU Jinru(Key Laboratory of Biopharmaceutical Preparation and Delivery(Chinese Academy of Sciences),State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China)

机构地区：[1]中国科学院过程工程研究所生化工程国家重点实验室生物药制备与递送重点实验室(中国科学院),北京100190

出　　处：《化学与生物工程》2024年第12期15-23,共9页Chemistry & Bioengineering

基　　金：建生鲜药创研基金项目(JSJC-20202104-056);内蒙古自治区科技成果转化专项资金项目(2019自-成-26)。

摘　　要：糖尿病一直是严重威胁人类健康及生活质量的疾病,α-葡萄糖苷酶抑制剂(α-glucosidase inhibitors,AGI)是治疗Ⅱ型糖尿病的首选药物,但目前临床常用的AGI药物受到成本相对较高且有显著不良反应的困扰。降糖植物是获得低副作用、多靶点、高催化活性的天然AGI的重要来源,利用微生物强大的代谢网络和丰富的酶系提高降糖植物中AGI活性物质含量及生物活性、经过生物转化获得新型AGI已成为研究热点。探究了微生物发酵对降糖植物AGI活性物质的转化作用,并对微生物发酵在提高降糖植物α-葡萄糖苷酶抑制活性的应用进展进行了综述,为进一步深入挖掘和研发高效安全的天然AGI药物提供了参考。Diabetes has become a serious disease endangering human health and life quality,andα-glucosidase inhibitors(AGI)are effective drugs for treating typeⅡdiabetes.However,currently commonly used AGI drugs in clinical practice are plagued by relatively high costs and significant adverse reactions.Hypoglycemic plants are important sources of natural AGI with low side effects,multiple targets,and high catalytic activity.Recently,a research hotspot focuses on utilizing the powerful metabolic network and complex enzyme systems of microorganisms to increase the content and biological activity of AGI active substances in hypoglycemic plants and even to obtain new AGI through biological transformation.In this review,we explore the conversion effect of microbial fermentation on AGI active substances in hypoglycemic plants,and summarize the application progress in microbial fermentation to enhanceα-glucosidase inhibitory activity in hypoglycemic plants.The study provides theoretical reference for further exploration and development of efficient and safe natural AGI drugs.

关 键 词：糖尿病 α-葡萄糖苷酶抑制剂(AGI) 微生物发酵 降糖植物 

分 类 号：TQ92[轻工技术与工程—发酵工程] Q815[生物学—生物工程] R587.1[医药卫生—内分泌]