BUB1B与妇科恶性肿瘤  

BUB1B and gynecological malignant tumors

作　　者：候壹颖 魏芳[1] HOU Yiying;WEI Fang(Department of Gynecology,the Second Hospital of Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西医科大学第二医院妇产科,山西太原030000

出　　处：《基础医学与临床》2024年第12期1717-1721,共5页Basic and Clinical Medicine

基　　金：山西省自然科学基金(20210302123272)。

摘　　要：有丝分裂检查点丝氨酸/苏氨酸激酶B(BUB1B)能够通过防止细胞在一个或多个动点没有附着到纺锤体的情况下进入有丝分裂后期,维持有丝分裂染色体分离的高保真度,在信号转导和着丝粒稳定附着到微管过程中均发挥着主要作用。BUB1B表达失调可能影响细胞有丝分裂诱导非整倍体发生、染色体不稳定及异常的细胞生物学功能导致细胞恶性转化。本文对BUB1B在子宫内膜癌,卵巢癌及宫颈癌发生与发展中的作用作一简要回顾与分析。The BUB1 mitotic checkpoint serine/threonine kinase B(BUB1B)maintains a high fidelity of mitotic chromosome segregation by preventing the initiation of anaphase without the attachment of one or more kinetochore to the spindle,and plays a major role in both signal transduction and the stable attachment of kinetochore to microtubules.The dysregulated expression of BUB1B may affect the occurrence of mitosis-induced aneuploidy,chromosome instability and abnormal cell biological function,leading to cell malignant transformation.This review summarizes the role of BUB1B in the occurrence and development of gynecological malignant tumors.

关 键 词：BUB1有丝分裂检查点丝氨酸/苏氨酸激酶B(BUB1B) 妇科恶性肿瘤 有丝分裂 

分 类 号：R73[医药卫生—肿瘤]