青少年与成年抑郁症患者血浆Maresin-1和炎性因子水平失衡的差异  

Differences in plasma Maresin-1 and inflammatory factor imbalance between adolescent and adult patients with depression

作　　者：李嫣然 王慧颖 张金玉 王欣宇 邱晨 邵美琪 张怡璇 全柯铭 王长虹[1,2,3] Li Yanran;Wang Huiying;Zhang Jinyu;Wang Xinyu;Qiu Chen;Shao Meiqi;Zhang Yixuan;Quan Keming;Wang Changhong(The Second Affiliated Hospital of Xinxiang Medical College,The Second Clinical College,Xinxiang 453002,China;Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorder,Xinxiang 453002,China;Brain Institute,Henan Academy of Innovations in Medical Science,Xinxiang 453002,China)

机构地区：[1]新乡医学院第二附属医院第二临床学院,新乡453002 [2]精神心理疾病防治河南省协同创新中心,新乡453002 [3]河南省医学科学院脑科学研究所,新乡453002

出　　处：《中华行为医学与脑科学杂志》2024年第11期1027-1033,共7页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金(81671346);河南省重点研发专项(221111311000);河南省自然科学基金(232300420280);中原英才计划(育才系列);精神心理疾病防治河南省协同创新中心规划课题(XTgh03)。

摘　　要：目的探讨青少年和成年抑郁症患者炎性因子水平失衡的差异。方法2022年1月至2023年8月纳入青少年及成年抑郁症患者各30例,青少年及成年健康对照各30例。检测各组白细胞介素-6(interleukin 6,IL-6)、白细胞介素-17(interleukin 17,IL-17)、白细胞介素-10(interleukin 10,IL-10)、转化生长因子-β1(transforming growth factor-beta1,TGF-β1)、特异性促炎症消退因子-1(Maresin-1,MaR1)水平;采用汉密尔顿抑郁量表-24项(24-item Hamilton depression scale,HAMD-24)评估抑郁严重程度。采用SPSS 26.0软件进行t检验、协方差分析、Spearman相关分析和多因素二元Logistic回归,并通过受试者工作特征曲线评估炎性因子对抑郁症的预测价值。结果(1)青少年抑郁组患者IL-6[(64.000±38.632)pg/mL]、IL-17[(239.132±49.757)pg/mL]与TGF-β1[(737.267±328.447)pg/mL]水平均高于青少年对照组[(32.396±16.330)pg/mL,(214.954±42.326)pg/mL,(454.542±297.194)pg/mL](均P<0.05),MaR1[(21381.301±3946.011)pg/mL]水平低于青少年对照组[(30130.738±10278.999)pg/mL](P<0.001),IL-17水平与HAMD-24总分(r=0.429)、病程(r=0.571)呈正相关,IL-10水平与体重因子分(r=-0.384)呈负相关,TGF-β1水平与焦虑/躯体化因子分呈负相关(r=-0.449)(均P<0.05)。MaR1(B=0.0001,OR=0.9998,AUC=0.794,P<0.05)是青少年抑郁症患病的独立风险因素。(2)成年抑郁症患者IL-6、IL-17、IL-10、TGF-β1与MaR1水平均高于成年对照组(均P<0.05),TGF-β1水平与HAMD-24总分(r=-0.427)、焦虑/躯体化因子分(r=-0.368)、阻滞因子分(r=-0.405)、绝望感因子分(r=-0.398)呈负相关,MaR1水平与起病年龄呈正相关(r=0.425)(均P<0.05)。MaR1(B=0.0004,OR=1.0003,AUC=0.874,P<0.001)与IL-6(B=0.0399,OR=1.0407,AUC=0.779,P<0.05)是成年人抑郁症患病的独立风险因素,IL-6联合MaR1的AUC为0.938。结论青少年与成年抑郁症患者免疫失衡潜在机制存在差异,MaR1可能是青少年与成年抑郁症诊断的生物标志物。ObjectiveTo explore the difference of inflammatory factor imbalance between adolescent and adult patients with depression.MethodsA total of 30 adolescent and 30 adult patients with depression,and 30 adolescent and 30 adult healthy controls were included from January 2022 to August 2023.Interleukin-6(IL-6),interleukin-17(IL-17),transforming growth factor-beta1(TGF-β1),interleukin-10(IL-10)and Maresin-1(MaR1)level were detected by enzyme-linked immunosorbent assay.24-item Hamilton depression scale(HAMD-24)was used to assess the severity of depression in all depressed patients.SPSS 26.0 statistical software was used for t-test,covariance analysis,Spearman analysis and multivariate binary logistic regression,and the predictive value of selected inflammatory factors in depression was evaluated by receiver operating characteristic(ROC)curve.Results(1)In adolescent group,the levels of IL-6((64.000±38.632)pg/mL),IL-17((239.132±49.757)pg/mL),and TGF-β1((737.267±328.447)pg/mL)in patients with depression were higher than those in control group((32.396±16.330)pg/mL,(214.954±42.326)pg/mL,(454.542±297.194)pg/mL,all P<0.05),while the level of MaR1((21381.301±3946.011)pg/mL)was significantly lower than that in control group((30130.138±10278.999)pg/mL)(P<0.001).The level of IL-17 was positively correlated with the total score of HAMD-24(r=0.429)and the course of disease(r=0.571),the level of IL-10 was negatively correlated with body weight factor score(r=-0.384),and the levels of TGF-β1 was negatively correlated with anxiety/somatization factor score(r=-0.449)(all P<0.05)in adolescent patients with depression.MaR1(B=0.0001,OR=0.9998,AUC=0.794,P<0.05)was an independent risk factor for adolescents depression.(2)In adult depression group,the levels of IL-6,IL-17,IL-10,TGF-β1 and MaR1 were higher than those in adult control group(all P<0.05).The level of TGF-β1 in adult depression group was negatively correlated with the total score of HAMD-24(r=-0.427),the score of anxiety/somatization factor(r=-0.368),the score of bloc

关 键 词：抑郁症 青少年 免疫失衡机制 特异性促炎症消退因子-1 诊断生物标志物 

分 类 号：R749.4[医药卫生—神经病学与精神病学]