单侧烟雾病  

Unilateral moyamoya disease

作　　者：王愚 宫煜晨 李冰[2] 郇林春[2] Wang Yu;Gong Yuchen;Li Bing;Huan Linchun(Clinical Medicine School of Shandong Second Medical University,Weifang 276000,China;Department of Neurosurgery,Linyi People's Hospital Affiliated to Shandong Second Medical University,Linyi 276000,China)

机构地区：[1]山东第二医科大学临床医学院,潍坊276100 [2]山东第二医科大学附属临沂市人民医院神经外科,临沂276000

出　　处：《国际脑血管病杂志》2024年第7期549-553,共5页International Journal of Cerebrovascular Diseases

摘　　要：烟雾病是一种慢性脑血管病,其特征是以颈内动脉末端为中心的动脉发生狭窄或闭塞,并伴有异常血管网形成。如果这些脑血管造影结果仅见于一侧大脑半球,则为单侧烟雾病。众多研究表明,单侧烟雾病并不罕见。最新版诊断标准已将单侧烟雾病明确诊断为烟雾病,而不再是"可能的"烟雾病。该病的发病机制涉及遗传、免疫和环境因素,但确切病因目前尚不明确。与双侧烟雾病相比,单侧烟雾病具有不同的临床特征和影像学表现,其手术转归更好,且有很多危险因素促使其向对侧进展。文章对单侧烟雾病的流行病学、发病机制、临床特征、治疗及手术转归进行了综述,并对未来的研究方向进行了展望。Moyamoya disease is a chronic cerebrovascular disease characterized by stenosis or occlusion at the terminal portion of the internal carotid artery,accompanied by the formation of an abnormal vascular network.If these cerebral angiography findings are only seen in one hemisphere of the brain,it is unilateral moyamoya disease(U-MMD).Numerous studies have shown that U-MMD is not uncommon.The latest version of diagnostic criteria has clearly diagnosed U-MMD as Moyamoya disease,rather than being a"possible"moyamoya disease.The pathogenesis of this disease involves genetic,immune,and environmental factors,but the exact cause is currently unclear.Compared with the bilateral moyamoya disease,the U-MMD has different clinical features and imaging manifestations,and has better surgical outcome,and many risk factors promote its progression to the contralateral side.This article reviews the epidemiology,pathogenesis,clinical characteristics,treatment,and surgical outcome of U-MMD,and looks forward to the future research directions.

关 键 词：烟雾病 神经影像 疾病遗传易感性 疾病恶化 脑血管重建术 治疗结果 

分 类 号：R743[医药卫生—神经病学与精神病学]