唾液酸乳糖的功能及制备研究进展  

Research progress on the function and preparation of sialyllactose

作　　者：韩乐闪 于潇頔 栾庆民[1,2] 薛雅莺 孔刘娟[1,2] 李珍珍 李克文 HAN Leshan;YU Xiaodi;LUAN Qingmin;XUE Yaying;KONG Liujuan;LI Zhenzhen;LI Kewen(Baolingbao Biology Co.,Ltd.,Yucheng 251200;Shandong Provincial Key Laboratory of Functional Sugar Extraction and Application Technology,Yucheng 251200)

机构地区：[1]保龄宝生物股份有限公司,禹城251200 [2]山东省功能糖提取与应用技术重点实验室,禹城251200

出　　处：《中国食品添加剂》2024年第12期242-250,共9页China Food Additives

基　　金：2020年度山东省重点研发计划(2020CXGC010601)。

摘　　要：母乳低聚糖(human milk oligosaccharides,HMOs)既可以作为益生元,促进双歧杆菌等有益肠道微生物的定植生长;也可以作为诱饵受体,抑制致病微生物附着在结肠黏膜上;还可以作为免疫调节剂和结肠成熟刺激剂。其中唾液酸乳糖因其在促进婴幼儿发育、抗病毒以及改善肠道健康等方面的作用,根据2023年最新美国和欧盟的法规规定,已被允许作为营养强化剂应用于婴幼儿配方食品和保健品中。唾液酸乳糖最常见的两种为3'-唾液酸乳糖(3'-Sialyllactose,3'-SL)和6'-唾液酸乳糖(6'-Sialyllactose,6'-SL),通常是HMOs所含唾液酸化寡糖中含量最高的两种,在食品及制药行业的商业价值及应用潜力巨大,本文主要简述两种唾液酸乳糖的生理功能及生物合成进程。Human milk oligosaccharides(HMOs)can serve as prebiotics,promoting the colonization and growth of beneficial intestinal microorganisms such as bifidobacterium.They can also act as decoy receptors,inhibiting the adhesion of pathogenic microorganisms to the colon mucosa;they can also be used as immunomodulators and colon maturation stimulators.Among them,sialyllactose has garnered attention for its roles in promoting infant development,antiviral and improving intestinal health,according to the latest regulations of the United States and the European Union in 2023,it has been allowed to be used as a nutritional fortifier in infant formula and health products.The two most common types of sialyllactose are 3'-Sialyllactose(3'-Sialyllactose,3'-SL)and 6'-sialyllactose(6'-SL),which are usually the two most abundant of the sialyllactose oligosaccharides found in HMOs.They have great commercial value and application potential in the food and pharmaceutical industries.The physiological function and biosynthesis process of two kinds of sialyllactose are reviewed in this paper.

关 键 词：母乳低聚糖 唾液酸乳糖 生理功能 制备方法 

分 类 号：TS202.3[轻工技术与工程—食品科学] TS218[轻工技术与工程—食品科学与工程]