Recent progress in pyroptosis probes and inducers  

作　　者：Aijing Zhang Jianguo Zheng Xin Qin Nengwang Yu Kang-Nan Wang 

机构地区：[1]Department of Urology,Qilu Hospital of Shandong University,Jinan 250100,China [2]Cheeloo College of Medicine,Shandong University,Jinan,Jinan 250012,China [3]State Key Laboratory of Crystal Materials,Shandong University,Jinan 250100,China [4]Shenzhen Research Institute of Shandong University,Shenzhen 518057,China

出　　处：《Advanced Sensor and Energy Materials》2024年第2期41-59,共19页先进传感器与能源材料（英文）

摘　　要：Pyroptosis is a newly identified form of regulated cell death driven by pathogen-associated molecular patterns(PAMPs),environment-or host-derived damage-associated molecular patterns(DAMPs),gram-negative bacteria,and chemotherapy drugs.Emerging evidence shows the potential of pyroptosis for biosensor development and cancer therapy,particularly for treating cancers resistant to traditional therapies.However,the published pyroptosis reviews mainly focused on multiple pyroptosis mechanisms and pathways.Therefore,it is timely to summarize the application of pyroptosis-based fluorescent probes highlighted by their detection capabilities and sensitivity as well as promising pyroptosis-inducing agents(including small molecules and nanomaterials)for cancer therapy.In this review,we comprehensively reviewed the current strategies for both probes and inducers to diagnosis or fight against cancers based on pyroptosis.We also highlighted the advantages of their strategies of design,mechanism,and application and provided new insights to overcome their challenges.

关 键 词：PYROPTOSIS Fluorescent probe Cancer therapy Cell death NANOMATERIALS 

分 类 号：R73[医药卫生—肿瘤]