Suppressing neuroinflammation using the near-infrared light emitted by (Sr,Ba)Ga_(12)O_(19): Cr^(3+) phosphor  

作　　者：Qi Liu Fangmei Yu Hossein Chamkouri Yanguang Guo Ping Chen Bo Wang Dongwei Liu Lei Chen 

机构地区：[1]Hefei University of Technology,School of Materials Science and Engineering,Hefei,China [2]Chinese Academy of Sciences,Brain Cognition and Brain Disease Institute of Shenzhen Institute of Advanced Technology,Shenzhen,China [3]Wuyi University,School of Applied Physics and Materials,Wuyi,China [4]Second Affiliated Hospital of Anhui Medical University,Department of Ophthalmology,Hefei,China [5]Intelligent Manufacturing Institute of Hefei University of Technology,Hefei,China

出　　处：《Advanced Photonics Nexus》2024年第3期68-80,共13页先进光子学通讯（英文）

基　　金：supported by the National Natural Science Foundation of China(Grant No.21875058);the Natural Science Foundation of Anhui Province(Grant No.2208085J13);the Major Science and Technology Project of Anhui Province(Grant No.202103a05020025);the Open Foundation of National Joint Engineering Research Center for Abrasion Control and Molding of Metal Materials of Henan University of Science and Technology(Grant No.HKDNM2019015);the Major Science and Technology Project of Zhongshan City of Guangdong Province on the Strategic Emerging Industries Technology Research Topic,China(Grant No.2022A1007).

摘　　要：Neurodegenerative diseases,such as Parkinson’s and Alzheimer’s diseases,affect the elderly worldwide and will become more prevalent as the global population ages.Neuroinflammation is a common characteristic of neurodegenerative diseases.By regulating the phenotypes of microglia,it is possible to suppress neuroinflammation and,in turn,help prevent neurodegenerative diseases.We report a noninvasive photonic approach to regulating microglia from overexcited M1/M2 to the resting M0 phenotype using a special near-infrared(NIR)light emitted by the SrGa_(12)O_(19)∶Cr^(3t) phosphor.The absorbance and internal and external quantum efficiencies of the optimal SreGa_(0.99)Cr_(0.01)_(12)O_(19) phosphor synthesized at 1400℃ for 8 h using 1%H_(3)BO_(3) t 1%AlF3 as flux are 53.9%,99.2%,and 53.5%;the output power and energyconversion efficiency of the LED device packaged using the optimal SrGa_(12)O_(19): Cr^(3+) phosphor driven at 20 mA reach unprecedentedly 19.69 mW and 37.58%,respectively.The broadband emission of the NIR LED device covers the absorption peaks of cytochrome c oxidase well,and the NIR light can efficiently promote the proliferation of microglia,produce adenosine triphosphate(ATP),reverse overexcitation,alleviate and inhibit inflammation,and improve cell survival rate and activity,showing great prospects for photomedicine application.

关 键 词：near-infrared light LED SrGa_(12)O_(19):Cr^(3+)phosphor PHOTOBIOMODULATION NEUROINFLAMMATION microglia. 

分 类 号：R74[医药卫生—神经病学与精神病学]