2011—2023年贵州省蘑菇中毒疾病负担现状及变化趋势分析  

Analysis of the burden and trend of mushroom poisoning diseases in Guizhou Province from 2011 to 2023

作　　者：吴牡丽 熊涑钫 陈庆园 吴安忠 左佩佩 王青 李军[1] 郭华[1,2] WU Mu-li;XIONG Su-fang;CHEN Qing-yuan;WU An-zhong;ZUO Pei-pei;WANG Qing;LI Jun;GUO Hua(School of Public Health and Health,Guizhou Medical University,Key Laboratory of Environmental Pollution and Disease Monitoring,Ministry of Education,Guiyang,Guizhou 561113,China;不详)

机构地区：[1]贵州医科大学公共卫生与健康学院,环境污染与疾病监控教育部重点实验室,贵州贵阳561113 [2]贵州省疾病预防控制中心公共卫生监测评价研究所,贵州贵阳550004 [3]贵州省疾病预防控制中心实验中心

出　　处：《现代预防医学》2024年第23期4291-4296,4314,共7页Modern Preventive Medicine

基　　金：国家重点研发计划项目(2017YFC1601805);黔科合支撑项目([2017]2972)。

摘　　要：目的了解2011—2023年贵州省蘑菇中毒疾病负担现状及变化趋势,为合理制定预防控制措施提供依据。方法对贵州省“食源性疾病暴发监测系统”中2011—2023年蘑菇中毒事件数据进行描述性分析;将蘑菇中毒死亡数据根据性别、年龄、年份进行整理,使用世界卫生组织疾病负担Excel计算模版计算早死所致生命损失年(YLLs),结合人力资本法估计贵州省蘑菇中毒间接造成的经济负担;采用joinpoint回归模型分析蘑菇中毒发病率、死亡率、YLLs率的时间变化趋势。结果2011—2023年贵州省共报告蘑菇中毒暴发事件2518起,发病8716人,死亡97人,死亡率为0.25/10万;全人群的YLLs为2139人年,YLLs率为5.55人年/10万,男性的YLLs与YLLs率均高于女性;45~<60岁人群的YLLs最高,60~<70岁人群的YLLs率最高;贵州省97例蘑菇中毒死亡病例总体间接经济负担为4085.69万元,人均42.12万元;2011—2023年贵州省蘑菇中毒发病率呈持续上升趋势,死亡率和YLLs率均呈持续下降趋势,即APC=AAPC,发病率、死亡率和YLLs率分别为26.79%、-17.76%、-16.70%(P<0.05)。结论贵州省蘑菇中毒发病率呈持续上升趋势,且男性YLLs大于女性、45~<60岁人群YLLs最高,与之对应的间接经济负担重,应及时加强有效的宣传教育、继续强化医疗救治,降低毒蘑菇中毒的发生。Objective To understand the current status and trends of the burden of mushroom poisoning diseases in Guizhou Province from 2011 to 2023,providing a basis for the formulation of rational prevention and control measures.Methods A descriptive analysis was conducted on mushroom poisoning incident data from the“Foodborne Disease Outbreak Monitoring System”in Guizhou Province from 2011 to 2023.The mushroom poisoning mortality data were organized by gender,age,and year.The World Health Organization’s Excel template was used to calculate Years of Life Lost(YLLs)due to premature death,and the human capital method was employed to estimate the indirect economic burden caused by mushroom poisoning in Guizhou Province.The Join point regression model was utilized to analyze the temporal trends in incidence rates,mortality rates,and YLLs rates of mushroom poisoning.Results From 2011 to 2023,Guizhou Province reported a total of 2518 mushroom poisoning outbreaks,affecting 8716 individuals and resulting in 97 deaths,with a mortality rate of 0.25 per 100000 population.The total YLLs for the entire population was 2139 person-years,with a YLLs rate of 5.55 person-years per 100000;YLLs and YLLs rates for males were higher than those for females.The highest YLLs were observed in the 45 to<60 age group,while the highest YLLs rate was found in the 60 to<70 age group.The overall indirect economic burden of the 97 mushroom poisoning deaths in Guizhou Province was 40.8569 million yuan,averaging 421200 yuan per case.From 2011 to 2023,the incidence rate of mushroom poisoning in Guizhou Province showed a continuous upward trend,while both the mortality rate and YLLs rate exhibited a continuous downward trend,with annual percentage changes(APC)of 26.79%,-17.76%,and-16.70%,respectively(P<0.05).Conclusion The incidence rate of mushroom poisoning in Guizhou Province is on a continuous rise,with higher YLLs in males compared to females and the highest YLLs observed in the 45 to<60 age group,corresponding to a significant indirect economic bu

关 键 词：蘑菇中毒 食源性疾病 疾病负担 Joinpoint趋势分析 

分 类 号：R155.3[医药卫生—营养与食品卫生学]