消化系统肿瘤标志物相关蛋白组学的研究进展  

Progress in research of proteomics related to digestive system tumor markers

作　　者：蔡晓晗 赵思琦 张锴[2] 刘文天[1] Xiao-Han Cai;Si-Qi Zhao;Kai Zhang;Wen-Tian Liu(Department of Gastroenterology,Tianjin Medical University General Hospital,Tianjin 300052,China;School of Basic Medical Sciences,Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津医科大学总医院消化内科,天津市300052 [2]天津医科大学基础医学院,天津市300070

出　　处：《世界华人消化杂志》2024年第10期716-726,共11页World Chinese Journal of Digestology

基　　金：天津医科大学总医院临床项目,No.22ZYYLCCG09.

摘　　要：消化系统肿瘤发病率及死亡率高,即使目前对其诊治的方法不断增多,但大多数仍不能被早期诊断,且预后不良.缺乏有效的生物标志物及治疗靶点是其不能早期诊断及进行有效治疗的原因.随着蛋白质组学技术的不断发展,蛋白质组学在探索肿瘤发生机制、寻找生物标志物和药物靶点等方面应用具有越来越重要的价值.本文综述了蛋白质组学技术在消化系统肿瘤生物标志物筛查中的应用进展,为消化系统肿瘤的早期诊断、预后判断及治疗提供新的思路.The incidence and mortality of digestive system tumors are high.Even though the number of methods for tumor diagnosis and treatment is increasing,most of these tumors still cannot be diagnosed early,and their prognosis is poor.The lack of effective biomarkers and therapeutic targets is the reason why they cannot be diagnosed early and treated effectively.With the continuous development of proteomics technology,proteomics has become increasingly valuable in exploring the mechanisms of tumorigenesis and searching for biomarkers and drug targets.This article reviews the application progress of proteomics technology in screening of biomarkers for digestive system tumors,with an aim to provide new ideas for early diagnosis,prognosis,and treatment of digestive system tumors.

关 键 词：蛋白质组学 质谱 生物标志物 消化系统肿瘤 

分 类 号：R735[医药卫生—肿瘤]