Flexible Copper‑Doped Silica Fibers Promote Infected Conjunctival Tissue Repair Through Antibacterial and Anti‑inflammatory Effects  

作　　者：Jie Cui Yuchen Cai Xiao Yu Yihong Shen Tianyi Zhou Binbin Sun Pengfei Cai Zhengchao Yuan Muhammad Shafiq Mohamed EL‑Newehy Hany EL‑Hamshary Xingping Zhou Yao Fu Xiumei Mo 

机构地区：[1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative Medicine,College of Biological Science and Medical Engineering,Donghua University,Shanghai 201620,People’s Republic of China [2]Department of Ophthalmology,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,People’s Republic of China [3]Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology,Shanghai 200011,People’s Republic of China [4]Innovation Center of NanoMedicine,Kawasaki Institute of Industrial Promotion,3‑25‑14 Tono‑machi,Kawasaki‑ku,Kanagawa 210‑0821,Japan [5]United Graduate School of Drug Discovery and Medical Information Sciences,Gifu University,1‑1 Yanagido,Gifu 501‑1193,Japan [6]Department of Chemistry,College of Science,King Saud University,P.O.Box 2455,11451 Riyadh,Saudi Arabia

出　　处：《Advanced Fiber Materials》2024年第1期278-296,共19页先进纤维材料（英文）

基　　金：supported by Science and Technology Commission of Shanghai Municipality,China(Nos.20S31900900,20DZ2254900);Sino German Science Foundation Research Exchange Center,China(M-0263);China Education Association for International Exchange(2022181);supported by Researchers Supporting Project Number(RSP2024R65);King Saud University,Riyadh,Saudi Arabia.Moreover,this project was supported by the State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua University(KF2109);National Natural Science Foundation of China(No.82070919 and 82271041);the Program of Shanghai Academic/Technology Research Leader(22XD1401800);the Biomaterials and Regenerative Medicine Institute Cooperative Research Project,Shanghai Jiao Tong University School of Medicine(2022LHA06);Shanghai Key Clinical Specialty,and Shanghai Eye Disease Research Center(2022ZZ01003);supported by the Fundamental Research Funds for the Central Universities(CUSF-DH-T-2023064).

摘　　要：The conjunctiva is crucial in safeguarding the eye from harm or infection,thereby ensuring the preservation of the vision.The repair of infected conjunctival damage is necessary.The objective of this study is to develop copper-doped flexible silica nanofibers(SiO_(2)@Cu NFs)with multifunctional antibacterial and anti-inflammatory characteristics.The continuous release of copper ions from electrospun membranes is shown to be effective to promote antibacterial and bioactive functions.Nanofiber membranes also exhibit biocompatibility and promote cell growth,angiogenesis,and inflammation modulation.In vivo evaluations further reveal the therapeutic efficacy of SiO_(2)@Cu NFs to promote the structural and the functional recoveries of the conjunctiva.Taken together,SiO_(2)@Cu NFs may hold significant promise for the fabrication of alterna-tive ocular bandage to suppress bacterial infection and promote repair of ocular tissues and may potential be also used for related disciplines.

关 键 词：Conjunctival reconstruction Inorganic nanofiber Bacterial infection ANGIOGENESIS ANTI-INFLAMMATION 

分 类 号：TB34[一般工业技术—材料科学与工程]