Helicobacter pylori infection is associated with the risk and phenotypes of cholelithiasis:A multi-center study and meta-analysis  

作　　者：Shuo-Yi Yao Xin-Meng Li Ting Cai Ying Li Lun-Xi Liang Xiao-Ming Liu Yu-Feng Lei Yong Zhu Fen Wang 

机构地区：[1]Department of Gastroenterology,The Third Xiangya Hospital,Central South University,Changsha 410013,Hunan Province,China [2]Hunan Key Laboratory of Nonresolving Inflammation and Cancer,The Third Xiangya Hospital,Central South University,Changsha 410006,Hunan Province,China [3]Health Management Center,The Third Xiangya Hospital,Central South University,Changsha 410013,Hunan Province,China [4]Department of Gastroenterology,Shanxi Coal Central Hospital,Taiyuan 030006,Shanxi Province,China [5]Department of Gastroenterology,The First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China

出　　处：《World Journal of Gastroenterology》2024年第47期4991-5006,共16页世界胃肠病学杂志（英文）

基　　金：Supported by the National Natural Science Foundation of China,No.82270594;the National Natural Science Foundation for Youths of China,No.82103151;the Outstanding Youth Foundation of Hunan Province,No.2022JJ20092;the Wisdom Accumulation and Talent Cultivation Project of Third Xiangya Hospital of Central South University,No.YX202103.

摘　　要：BACKGROUND Helicobacter pylori(H.pylori)is a prevalent pathogen associated with various diseases.Cholelithiasis is also a common condition.H.pylori infection has been identified in the biliary system,suggesting its potential involvement in biliary diseases.However,the specific role of H.pylori in the development of cholelithiasis remains inconclusive.AIM To investigate the potential association between H.pylori infection and the development of cholelithiasis.METHODS We performed a retrospective study in more than 70000 subjects in health examination center from 3 institutions in the middle,northern and eastern China,from October 2018 to December 2021,to explore the potential association between H.pylori and cholelithiasis through univariate and multivariate analysis.Meanwhile,the influence of H.pylori on biliary-related parameters was investigated.A comprehensive analysis of previous studies concerned about H.pylori and cholelithiasis was also executed.RESULTS In our multi-center study,H.pylori was positively associated with cholelithiasis[odds ratio(OR)=1.103,95%confidence interval(CI):1.001-1.216,P=0.049].Furthermore,H.pylori patients had less total and direct bilirubin than uninfected patients,while the total cholesterol and low-density lipoprotein cholesterol were more in H.pyloripositive participants(P<0.05).In the published articles,the cohort studies indicated H.pylori was a risk factor of cholelithiasis(hazard ratio=1.3280,95%CI:1.1810-1.4933,P<0.0001).The pooled results of case-control and crosssectional studies showed positive association between H.pylori and cholelithiasis in Asia(OR=1.5993,95%CI:1.0353-2.4706,P=0.034)but not in Europe(OR=1.2770,95%CI:0.8446-1.9308,P=0.246).Besides,H.pylori was related to a higher choledocholithiasis/cholecystolithiasis ratio(OR=3.3215,95%CI:1.1034-9.9986,P=0.033).CONCLUSION H.pylori is positively correlated with cholelithiasis,choledocholithiasis phenotype particularly,especially in Asia,which may be relevant to bilirubin/cholesterol metabolism.Cohort studies confirm

关 键 词：Helicobacter pylori CHOLELITHIASIS BILIRUBIN CHOLESTEROL MULTI-CENTER 

分 类 号：R573.3[医药卫生—消化系统] R735.34[医药卫生—内科学]