Current and future perspectives in the management and treatment of colorectal cancer  

作　　者：Sigfredo E Romero-Zoghbi Evita Krumina Fernando López-Campos Felipe Couñago 

机构地区：[1]Department of Radiation Oncology,GenesisCare Talavera de la Reina,Toledo 45600,Spain [2]Department of Radiation Oncology,GenesisCare Guadalajara,Guadalajara 19004,Spain [3]Department of Radiation Oncology,Hospital Universitario Ramón Y Cajal,Madrid 28034,Spain [4]Department of Radiation Oncology,GenesisCare-Hospital Universitario Vithas Madrid La Milagrosa,Madrid 28010,Spain

出　　处：《World Journal of Clinical Oncology》2025年第2期9-17,共9页世界临床肿瘤学杂志（英文）

摘　　要：In this editorial,we reviewed the article by Fadlallah et al that was recently published in the World Journal of Clinical Oncology.The article provided a comprehensive and in-depth view of the management and treatment of colorectal cancer(CRC),one of the leading causes of cancer-related morbidity and mortality worldwide.The article analyzed the therapeutic modalities and their sequencing,focusing on total neoadjuvant therapy for locally advanced rectal cancer.It highlighted the role of immunotherapy in tumors with high microsatellite instability or deficient mismatch repair,addressing recent advances that have improved prognosis and therapeutic response in localized and metastatic CRC.Innovations in surgical techniques,advanced radiotherapy,and systemic agents targeting specific mutational profiles are also discussed,reflecting on how they revolutionized clinical management.Circulating tumor DNA has emerged as a promising tool for detecting minimal residual disease,prognosis,and therapeutic monitoring,solidifying its role in precision oncology.This review emphasized the importance of technological and therapeutic advancements in improving clinical outcomes and personalizing CRC treatment.

关 键 词：Colorectal cancer Metastatic colorectal cancer Total neoadjuvant therapy CHEMORADIOTHERAPY Colon surgery Rectal surgery CHEMOTHERAPY IMMUNOTHERAPY 

分 类 号：R735.34[医药卫生—肿瘤]