Spectrum of venous thromboembolism in adult patients with ulcerative colitis in Pakistan:A single center retrospective study  

作　　者：Masood Muhammad Karim Hafsa Shaikh Faisal Wasim Ismail 

机构地区：[1]Department of Medicine,The Aga Khan University Hospital,Karachi 74800,Pakistan [2]Department of General Surgery,The Aga Khan University Hospital,Karachi 74800,Pakistan

出　　处：《World Journal of Clinical Cases》2025年第6期9-13,共5页世界临床病例杂志（英文）

摘　　要：BACKGROUND Patients with inflammatory bowel disease are at a 2-8-fold higher risk of deve-loping venous thromboembolism(VTE)as compared to the general population.Although the exact pathogenesis is unclear,the literature suggests that increased risk of thromboembolic events in such patients occurs as a result of increased coagulation factors,inflammatory cytokines,and reduction in anticoagulants leading to a prothrombotic state.AIM To assess the prevalence,risk factors,management,and outcome of ulcerative colitis(UC)patients who develop VTE.METHODS This was a retrospective chart review done in The Gastroenterology Department of The Aga Khan University Hospital.Data was collected from medical records for all patients admitted with a diagnosis of UC from January 2012 to December 2022.RESULTS Seventy-four patients fulfilled the inclusion criteria.The mean±SD of age at presentation of all UC patients was 45 years±10 years whereas for those who developed VTE,it was 47.6 years±14.7 years.Hypertension and diabetes were the most common co-morbid seen among UC patients with a frequency of 17(22.9%)and 12(16.2%),respectively.A total of 5(6.7%)patients developed VTE.Deep venous thrombosis was the most common thromboembolic phenomenon seen in 3(60%)patients.All the patients with UC and concomitant VTE were discharged home(5;100%).CONCLUSION The prevalence of VTE with UC in Pakistani patients corresponds with the international literature.However,multi-centric studies are required to further explore these results.

关 键 词：Deep venous thrombosis Inflammatory bowel disease Low-middle-income country ANTICOAGULATION Protein C deficiency 

分 类 号：R735[医药卫生—肿瘤]