Calculus bovis hijacks the tumor microenvironment in liver cancer cells in a multifaceted approach:A falling row of dominoes  

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作  者:Said G Farhat Karam Karam 

机构地区:[1]Department of Internal Medicine,Division of Gastroenterology,Saint Georges Hospital University Medical Center,Beirut 3187,Beyrouth,Lebanon [2]Department of Gastroenterology,Dr.Sulaiman Al habib,Dubai 505005,Dubai,United Arab Emirates [3]Department of Gastroenterology,University of Balamand,Beirut 3187,Beyrouth,Lebanon

出  处:《World Journal of Gastroenterology》2024年第48期5221-5224,共4页世界胃肠病学杂志(英文)

摘  要:Calculus bovis(C.bovis)is widely used in traditional Chinese medicine due to its anti-tumor effects.C.bovis shifts liver cancer tumor microenvironment towards regression by hindering tumor-associated macrophages polarization.Huang et al have demonstrated in their study that C.bovis inhibits M2-tumour-associated macrophages(TAM)polarization by halting the Wnt/β-catenin pathway.The mechanism of action by which C.bovis exerts its anti-tumor effects is multifaceted and includes network pharmacology,transcriptomics and molecular docking.In vitro assays demonstrated that C.bovis-containing serum inhibited M2-TAMs polarization in human hepatocellular carcinomas cells.C.bovis was found to have 22 active components of which 11 were detected in the bloodstream.The anti-neoplastic activity of C.bovis lies in suppressing M2-TAM polarization by modulation of the Wnt/B-catenin pathway.In vitro and in vivo experiments have shown that C.bovis suppresses M2-TAM polarization and halts the Wnt signaling pathway.The inhibitory effect of C.bovis on M2-TAM was reversed by SKL2001,a Wnt agonist,which highlights C.bovis’s selectivity and specificity.C.bovis inhibits M2-TAM polarization by modulating the Wnt/β-catenin pathway,thus impeding liver cancer growth.Owing to the“cross-talk”between transforming growth factor-β(TGF-β)signaling pathways,this paper highlights the potential significance of C.bovis in controlling the tumor microenvironment not only through hindering the polarization of M2-TAMs via the Wnt signaling pathway,but also by downregulating TGF-β.Therefore,C.bovis serves as an igniter to fuel a cascade of signaling events that culminates in the regression of the tumor microenvironment by compromising oncogenesis and angiogenesis.TGF-βis also Core Tip:Calculus bovis(C.bovis)is an herb used in traditional Chinese medicine known for its various anti-inflammatory and anti-tumorigenic effects.C.bovis influences the tumor microenvironment by targeting immune-related pathways.Transcriptome sequencing revealed that C.bov

关 键 词:CANCER inhibited SPECIFICITY 

分 类 号:R735.7[医药卫生—肿瘤]

 

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