Targeting hypoxia and angiogenesis in hepatocellular carcinoma:New insights and therapeutic strategies  

作　　者：Jia-Yi Du Chu-Ting Zhang Ting Li Ya-Ping Li 

机构地区：[1]Laboratory of Epidemiology and Public Health,Yale University School of Public Health,New Haven,CT 06510,United States [2]Department of Infectious Diseases,The Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,Shaanxi Province,China

出　　处：《World Journal of Hepatology》2024年第12期1371-1376,共6页世界肝病学杂志（英文）

基　　金：Supported by the Basic and Clinical Integration Project of Xi’an Jiaotong University,No.YXJLRH2022067.

摘　　要：In this manuscript we comment on the article by Yang et al published recently,focusing on how hepatic angiopoietin-2(Ang-2)transcription promote the pro-gression of hepatocellular carcinoma(HCC).HCC is one of the most common and lethal malignancies worldwide,especially in regions with high hepatitis B virus infection rates.Ang-2 is a key mediator of angiogenesis and plays a significant role in the progression of chronic liver diseases towards HCC,particularly in the hypoxic microenvironment.This paper reviews the dynamic expression of Ang-2 in hepatocarcinogenesis and its regulation by hypoxia-inducible factor-1α.Fur-thermore,we discuss Ang-2’s potential as an early monitoring biomarker for me-tastasis,and the therapeutic prospects of silencing hypoxia-inducible factor-1αto downregulate Ang-2 and suppress epithelial-mesenchymal transition in HCC treatment.

关 键 词：Hepatocellular carcinoma Hypoxia-inducible factor-1α ANGIOPOIETIN-2 ANGIOGENESIS Tumor microenvironment 

分 类 号：R735.7[医药卫生—肿瘤]