Clinical analysis of Klebsiella pneumoniae infection in patients with liver cirrhosis in Beijing  

作　　者：Yu Zhang Hong Zhao Shi-Bo Ji Hui-Chun Xing 

机构地区：[1]Center of Liver Diseases Division 3,Beijing Ditan Hospital,Capital Medical University,Peking University Ditan Teaching Hospital,Beijing 100015,China [2]Center of Liver Diseases Division 1,Beijing Ditan Hospital,Capital Medical University,Peking University Ditan Teaching Hospital,Beijing 100015,China

出　　处：《World Journal of Hepatology》2024年第12期1441-1449,共9页世界肝病学杂志（英文）

基　　金：Supported by the National Key R&D Program of China,No.2021YFC2301800.

摘　　要：BACKGROUND The incidence of Klebsiella pneumoniae(K.pneumoniae)infection in patients with cirrhosis has been increasing over recent years,posing certain difficulties in clinical treatment.AIM To analyze the clinical features of patients with liver cirrhosis and identify the risk factors to help the early diagnosis and treatment of these diseases.METHODS Clinical data and laboratory tests were collected from 72 patients with cirrhosis confirmed by secretion or blood culture of K.pneumoniae infection at Beijing Ditan Hospital,Capital Medical University,between May 2016 and October 2018.Data from hospitalized patients with liver cirrhosis and K.pneumoniae infections,in-cluding age,sex,antimicrobial use,length of stay,site of infection,distribution of pathogenic bacteria,complications,invasive operations,laboratory indicators,treatment,and clinical regression,were extracted and retrospectively analyzed.Clinical data and biochemical values were included in the multivariate logistic regression analysis.RESULTS A total of 52 men and 20 women,with an age range from 29 to 85 years and an average age of 57.7±12.54,were analyzed.The incidence of hospital K.pneu-moniae infection in patients with cirrhosis was approximately 19.44%.The most common the infection site was the bloodstream,followed by the respiratory tract,abdominal cavity,and biliary tract.Risk factors for infection were old age,long hospital stays,gastrointestinal bleeding,and low serum albumin levels,while prophylactic antibiotics were protective factors.The multivariate analysis suggested that other infections,chronic diseases,and invasive procedures were independent factors.CONCLUSION In clinical practice,the length of hospital stays should be shortened as much as possible,invasive operations should be reduced,antibiotics should be rationally used,and the patients’liver function should be timely improved.This is of great significance for reducing the incidence of hospital infection.

关 键 词：Klebsiella pneumoniae CIRRHOSIS ANTIBIOTICS Logistic regression Hospital infection 

分 类 号：R575.2[医药卫生—消化系统]