Nano-drug delivery systems integrated with low radiation doses for enhanced therapeutic efficacy in cancer treatment  

作　　者：Antonio Pontoriero Paola Critelli Marco Zeppieri Alberto Bosurgi Stefania Guercio Maria Caffo Filippo Flavio Angileri Silvana Parisi Salvatore Lavalle Stefano Pergolizzi 

机构地区：[1]Radiation Oncology Unit,Department of Biomedical,Dental Science and Morphological and Functional Images,University of Messina,Messina 98125,Italy [2]Department of Ophthalmology,University Hospital of Udine,Udine 33100,Italy [3]Neurosurgery Unit,Department of Biomedical,Dental Science and Morphological and Functional Images,Messina,Italy,Messina 98125,Italy [4]Lavalle,Department of Medicine and Surgery,University of Enna"Kore",Enna 94100,Italy

出　　处：《World Journal of Clinical Cases》2025年第10期14-27,共14页世界临床病例杂志（英文）

摘　　要：BACKGROUND Precision medicine is an emerging field that includes tumor-targeted delivery and tumor microenvironment.This review explores the synergistic potential of combining nano-drug delivery systems with low radiation doses to achieve optimized therapeutic outcomes,particularly in the context of cancer treatment.Nanoparticle-based drug carriers offer precise and targeted delivery,enhancing the therapeutic index of anticancer agents.The use of lower radiation doses has become a focus in radiation oncology to minimize off-target effects on healthy tissues in palliation treatment with high-target volume lesions.AIM To conduct a bibliometric review of nanomedicine and glioblastoma(GBM),all relevant studies from the last two decades were included.METHODS The search strategy comprised the keywords“nanomedicine”and“glioblastoma”in the title and/or abstract.All English-language documents from 1 January 2000 to 31 December 2023 were considered for the analysis.R code(version 4.2.0)with R Studio(version 2022.12.0-353)and the Bibliometrix package(version 4.0.1)were used for the analysis.A total of 680 documents were collected.RESULTS We analyzed the bibliometric features of nanomedicine in glioma.With the limitations of the research,our analysis aims to highlight the increasing interest of researchers in the precision medicine field in GBM treatment and lead us to suggest further studies focusing on the association between nanomedicine and radiotherapy.CONCLUSION Due to the poor prognosis associated with GBM,new therapeutic approaches are necessary.There is an increasing interest in precision medicine,which includes nanomedicine and radiotherapy,for GBM treatment.This integration enhances the efficacy of targeted treatments and provides a promising avenue for reducing adverse effects,signifying a notable advancement in precision oncology.

关 键 词：NANOMEDICINE NANOPARTICLES DRUG-DELIVERY RADIOTHERAPY Combination therapy 

分 类 号：R692[医药卫生—泌尿科学]