BAT-tling oxidative stress through BCAA catabolism  

作　　者：Maria Delgado-Martin Qiaoqiao Zhang Lawrence Kazak 

机构地区：[1]Rosalind&Morris Goodman Cancer Institute and Department of Biochemistry,McGill University,Montreal,QC,H3A 1A3,Canada [2]Department of Biochemistry,McGill University,Montreal,QC,H3G 1Y6,Canada

出　　处：《Life Metabolism》2024年第5期42-44,共3页生命代谢（英文）

基　　金：supported by Canadian Institutes of Health Research(CIHR)project grants(PJT-159529,PJT-190219,and PJT-180557);a Natural Sciences and Engineering Research Council of Canada(NSERC)Discovery Grant(to L.K.).

摘　　要：Elevated circulating levels of branched-chain amino acids(BCAAs)are associated with the development of type 2 diabetes and obesity,diseases that can be countered by the energy dissipating(thermogenic)function of brown adipose tissue(BAT).In a recent study published in Cell,Verkerke and colleagues report that BAT promotes insulin sensitivity in the liver by coupling antioxidant homeostasis with BCAA catabolism,an effect that is independent of its thermogenic properties.

关 键 词：BCAA properties. HOMEOSTASIS 

分 类 号：R587.1[医药卫生—内分泌]