Exploring age and gender disparities in cardiometabolic phenotypes and lipidomic signatures among Chinese adults: a nationwide cohort study  

作　　者：Xiaojing Jia Hong Lin Ruizhi Zheng Shuangyuan Wang Yilan Ding Chunyan Hu Mian Li Yu Xu Min Xu Guixia Wang Lulu Chen Tianshu Zeng Ruying Hu Zhen Ye Lixin Shi Qing Su Yuhong Chen Xuefeng Yu Li Yan Tiange Wang Zhiyun Zhao Guijun Qin Qin Wan Gang Chen Meng Dai Di Zhang Bihan Qiu Xiaoyan Zhu Jie Zheng Xulei Tang Zhengnan Gao Feixia Shen Xuejiang Gu Zuojie Luo Yingfen Qin Li Chen Xinguo Hou Yanan Huo Qiang Li Yinfei Zhang Chao Liu Youmin Wang Shengli Wu Tao Yang Huacong Deng Jiajun Zhao Yiming Mu Shenghan Lai Donghui Li Weiguo Hu Guang Ning Weiqing Wang Yufang Bi Jieli Lu for theC Study Group 

机构地区：[1]Department of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [2]Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases,Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People's Republic of China,Shanghai National Center for Translational Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [3]Department of Endocrine and Metabolic Diseases,The First Hospital of Jilin University,Changchun,Jilin 130021,China [4]Department of Endocrine and Metabolic Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China [5]Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou,Zhejiang 310051,China [6]Department of Endocrine and Metabolic Diseases,Affiliated Hospital of Guiyang Medical College,Guiyang,Guizhou 550004,China [7]Department of Endocrine and Metabolic Diseases,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China [8]Department of Endocrine and Metabolic Diseases,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [9]Department of Endocrine and Metabolic Diseases,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510120,China [10]Department of Endocrine and Metabolic Diseases,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China [11]Department of Endocrine and Metabolic Diseases,The Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China [12]Department of Endocrine and Metabolic Diseases,Fujian Provincial Hospital,Fujian Medical University,Fuzhou,Fujian 350003,China [13]Department of Endocrine and Metabolic Diseases,The First Hospital of Lanzhou University,Lanzhou,Gansu 730000,China [14]Department of Endocrine and Metabolic Disease

出　　处：《Life Metabolism》2024年第5期61-74,共14页生命代谢（英文）

基　　金：supported by the National Natural Science Foundation of China(82170819,82370810,91857205,82088102,and 82200998);the National Key Research and Development Program of China(2022YFC2505202 and 2021YFA1301103);the Science and Technology Commission of Shanghai Municipality(23JS1400900,23Y11908400,and 23XD1422400);the Innovative research team of high-level local universities in Shanghai.

摘　　要：Understanding sex disparities in modifiable risk factors across the lifespan is essential for crafting individualized intervention strategies.We aim to investigate age-related sex disparity in cardiometabolic phenotypes in a large nationwide Chinese cohort.A total of 254,670 adults aged 40 years or older were selected from a population-based cohort in China.Substantial sex disparities in the prevalence of metabolic diseases were observed across different age strata,particularly for dyslipidemia and its components.Generalized additive models were employed to characterize phenotype features,elucidating how gender differences evolve with advancing age.Half of the 16 phenotypes consistently exhibited no sex differences,while four(high-density lipoprotein[HDL]cholesterol,apolipoprotein A1,diastolic blood pressure,and fasting insulin)displayed significant sex differences across all age groups.Triglycerides,apolipoprotein B,non-HDL cholesterol,and total cholesterol demonstrated significant age-dependent sex disparities.Notably,premenopausal females exhibited significant age-related differences in lipid levels around the age of 40-50 years,contrasting with the relatively stable associations observed in males and postmenopausal females.Menopause played an important but not sole role in age-related sex differences in blood lipids.Sleep duration also had an age-and sex-dependent impact on lipids.Lipidomic analysis and K-means clustering further revealed that 58.6%of the 263 measured lipids varied with sex and age,with sphingomyelins,cholesteryl esters,and triacylglycerols being the most profoundly influenced lipid species by the combined effects of age,sex,and their interaction.These findings underscore the importance of age consideration when addressing gender disparities in metabolic diseases and advocate for personalized,age-specific prevention and management.

关 键 词：sex difference AGING metabolic diseases modifiable risk factors LIPIDOMICS 

分 类 号：R589[医药卫生—内分泌]