Development of a Pt(Ⅱ)compound based on indocyanine green@human serum albumin nanoparticles:integrating phototherapy,chemotherapy and immunotherapy to overcome tumor cisplatin resistance  

作　　者：Xue-Yu Man Ze-Wen Sun Shan-He Li Gang Xu Wen-Juan Li Zhen-Lei Zhang Hong Liang Feng Yang 

机构地区：[1]State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China),School of Chemistry and Pharmaceutical Sciences,Collaborative Innovation Center for Guangxi Ethnic Medicine,Guangxi Normal University,Guilin 541004,China

出　　处：《Rare Metals》2024年第11期6006-6022,共17页稀有金属（英文版）

基　　金：financially supported by the Natural Science Foundation of China(No.22077021);the Natural Science Foundation of Guangxi(No.2022GXNSFGA035003)。

摘　　要：Cisplatin resistance is the main cause for the failure of cancer therapy.To solve the problem,we proposed to develop a novel human serum albumin(HSA)nanoplatform to integrate chemotherapy,photothermal therapy(PTT)and immunotherapy.To this end,we obtained a platinum compound(C5)with significant cytotoxicity in the cisplatin-resistant SKOV-3 cells(SKOV-3/DDP),and then innovatively constructed photosensitizer(indocyanine green(ICG))-encapsulated HSAC5 complex nanoparticles(ICG@HSA-C5 NPs).The ICG@HSA-C5 NPs exhibited excellent photothermal performances in vitro and in vivo.Importantly,the in vivo results revealed that HSA enhanced the antitumor effect of C5 and that the combination of chemotherapy and PTT could significantly inhibit cisplatin-resistant tumor growth and improved the targeting abilities of C5 and ICG,and reduced their side effects.We also confirmed that ICG@HSA-C5 NPs killed the SKOV-3/DDP cells via gasdermin E(GSDME)-mediated pyroptosis and pyroptosis-induced immune responses,thereby synergistically leading to the death of the SKOV-3/DDP cells.

关 键 词：ANTICANCER PLATINUM ALBUMIN Combination therapy Cisplatin resistance 

分 类 号：R730.51[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]