Bread enriched with resveratrol:Influence of the delivery vehicles on its bioactivity  

作　　者：Andreia F.R.Silva Mariana Monteiro Rute Nunes Ana Baiao Susana S.Braga Bruno Sarmento Manuel A.Coimbra Artur M.S.Silva Susana M.Cardoso 

机构地区：[1]LAQV-REQUIMTE,Department of Chemistry,University of Aveiro,3810-193,Aveiro,Portugal [2]i3S,Instituto de Investigaçao e Inovaçao em Saúde,Universidade do Porto,Porto,Portugal [3]CESPU,Instituto de Investigaçao e Formaçao Avançada em Ciencias e Tecnologias da Saúde,Gandra,Portugal

出　　处：《Food Bioscience》2022年第5期428-435,共8页食品生物科学（英文）

基　　金：supported by the NETDIAMOND project POCI-01-0145-FEDER-016385,University of Aveiro and LAQV-REQUIMTE(UIDB/50006/2020);Andreia Silva acknowledges FCT for the Ph.D.grant SFRH/BD/142100/2018。

摘　　要：Trans-resveratrol(RSV)is recognised as a bioactive ingredient in the development of functional foods.Its stability,solubility,and bioavailability constraints can be overcome by delivery systems,not yet tested in foods.This study aims at evaluating the impact of two delivery systems on the stability,antioxidant activity,bioaccessibility and bioavailability of RSV integrated into a bread matrix:an inclusion complex of RSV andγ-cyclodextrin(γCD⋅RSV)and RSV loaded zein nanoparticles(nZ-RSV).Wheat bread was supplemented with 0.5%of pure RSV(RSV-bread)and equivalent amounts ofγ-CD⋅RSV and nZ-RSV.The amount of RSV recovered from the hydroethanolic extracts ofγ-CD⋅RSV-and nZ-RSV-bread was 70.3%and 62.8%of the initial amount,respectively,lower than RSV-bread extract,89.0%,indicating lower degradability during bread preparation.Both vehicles helped to retain RSV antioxidant activity but did not increase RSV bioaccessibility(c.a.40%for free RSV andγCD⋅RSV,and 29%for nZ-RSV).In vitro tests on intestinal cell monolayers showed that,after 4 h of contact,only 5.0%of the initially available amount of RSV was able to permeate the intestinal barrier in all samples.Thus,bread itself is a vehicle for RSV integration into our daily diet,without the need for an additional delivery system.

关 键 词：STILBENES LOAF Γ-CYCLODEXTRIN Zein nanoparticle BIOACCESSIBILITY Permeability assay 

分 类 号：TS201[轻工技术与工程—食品科学]