In vitro and In vivo oxidation and cleavage products of tocols:From chemical tuners to“VitaminEome”therapeutics.A narrative review  

作　　者：Farid Khallouki Somayya Saber Toufik Bouddine Lhoussain Hajji Bachir Elbouhali Sandrine Silvente-Poirot Marc Poirot 

机构地区：[1]Biology Department,Faculty of Sciences and Techniques Errachidia,Moulay Ismail University of Meknes,BP 509,Boutalamine,Errachidia,Morocco [2]Biology Department,Moulay Ismail University of Meknes,Faculty of Sciences,BP.11201 Zitoune,Meknes,Morocco [3]Cancer Research Center of Toulouse,UMR 1037 INSERM,UMR 5071 CNRS,University of Toulouse III,Equipe labellisee par la Ligue Nationale Contre le Cancer,Toulouse,France [4]French Network for Nutrition and Cancer Research(NACRe Network),France

出　　处：《Food Bioscience》2022年第5期1353-1373,共21页食品生物科学（英文）

摘　　要：Vitamin E components and vitamin E oxidation products(VEOP)define the“vitaminEome”.VEOP are produced through biological and chemical processes.They are found at low concentrations in vivo and may play particular biological functions linked with chemoprevention and inflammatory processes.Much data have been reported leading to more insight into VEOP.VEOP are generated through peroxy-radical generating systems and via reactive oxygen and nitrogen species as well as enzymatically by a variety of enzymes.In vivo,VEOP and their catabolites may reach the blood circulation and display physiological properties.This narrative review expands upon parent vitamin E chemistry as well as VEOP chemical concepts.The in vitro and in vivo routes by which they can be generated are exhaustively approached.Finally,we will discuss therapeutic and chemopreventive opportunities that VEOP offer with a special focus on their cytotoxic and anti-inflammatory functions.

关 键 词：Vitamin E Vitamin E oxidation products Chemistry Tocopherylquinones 5-Nitro-γ-tocopherol Vitamin E long chain metabolites CYTOTOXICITY Anti-inflammatory activities 

分 类 号：TS201.2[轻工技术与工程—食品科学]