青少年首发抑郁障碍患者自杀未遂影响因素分析  

Analysis of influencing factors of suicide attempt in adolescents with first-episode depressive disorder

作　　者：芦云平 周梦迪 于超[1] 宋丽华 张丽丽[1] 崔伟[1] LU Yun-ping;ZHOU Meng-di;YU Chao;SONG Li-hua;ZHANG Li-li;CUI Wei(Hebei Provincial Mental Health Center,Hebei Key Laboratory of Major Mental and Behavioral Disorders,The Sixth Clinical Medical College of Hebei University,Baoding 071000,China)

机构地区：[1]河北省精神卫生中心,河北省重大精神与行为障碍疾病研究重点实验室,河北大学第六临床医学院,071000

出　　处：《临床精神医学杂志》2024年第6期461-464,共4页Journal of Clinical Psychiatry

基　　金：河北省医学科学研究课题计划(20230186)。

摘　　要：目的:探讨青少年首发抑郁障碍患者自杀未遂的影响因素。方法:纳入2020年7月至2022年2月河北省精神卫生中心青少年首次抑郁障碍住院患者125例,根据有无自杀未遂分为伴自杀未遂组(51例)和不伴自杀未遂组(74例),比较两组患者人口学特征、疾病特征及相关指标。结果:伴自杀未遂组17项汉密尔顿抑郁量表(Hamilton depression rating scale-17,HAMD-17)中有罪感因子分、工作和兴趣因子分以及总分均高于不伴自杀未遂组;血同型半胱氨酸水平、甲状腺功能中游离甲状腺素(free thyroxine 4,FT4)均低于不伴自杀未遂组(P均<0.05)。HAMD-17总分(OR=1.194)、FT4(OR=0.051)与青少年首发抑郁障碍患者的自杀未遂相关联。结论:青少年首发抑郁障碍患者抑郁症状越严重,自杀未遂发生率越高;血清FT4水平与自杀未遂行为的发生呈负相关。Objective:To investigate the influencing factors of suicide attempt in adolescents with first-episode depressive disorder.Method:From July 2020 to February 2022,a total of 125 adolescents with first-episode depressive disorder in Hebei Provincial Mental Health Center were recruited,they were divided into a group with attempted suicide(51 cases)and a group without attempted suicide(74 cases).The demographic characteristics,disease characteristics and related indicators were compared between the two groups.Results:The scores of guilt factor,work and interest factor and total score of Hamilton depression rating scale-17(HAMD-17)in the attempted suicide group were higher than those in the non-attempted suicide group.The serum homocysteine level,free thyroxine 4(FT4)in thyroid function in the attempted suicide group were lower than those in the non-attempted suicide group(all P<0.05).The total score of HAMD-17(OR=1.194)and FT4(OR=0.051)were associated with suicidal behavior in adolescents with first-episode depressive disorder.Conclusion:The more severe the depressive symptoms of adolescent patients with first-episode depressive disorder,the higher the incidence of attempted suicide.The level of serum FT4 was negatively correlated with the occurrence of attempted suicide.

关 键 词：青少年 首发抑郁障碍 自杀未遂 影响因素 

分 类 号：R749.4[医药卫生—神经病学与精神病学]