青光眼视路损伤及脱髓鞘在青光眼神经损伤作用中的研究进展  

Advances on the neurodegeneration of visual pathway in glaucoma and the role of demyelination in glaucomatous optic neuropathy

作　　者：张莉 傅楹迪 王宁利 左晓玲 Zhang Li;Fu Yingdi;Wang Ningli;Zuo Xiaoling(Beijing Institute of Ophthalmology,Beijing Ophthalmology&Visual Sciences Key Laboratory,Beijing Tongren Hospital,Capital Medical University,Beijing 100005,China;Department of Surgery,Xingtai Central Hospital,Xingtai 054099,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京市眼科研究所,北京市眼科学与视觉科学重点实验室,100005 [2]河北省邢台市中心医院外科,054099

出　　处：《中华眼科医学杂志（电子版）》2024年第4期233-239,共7页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：国家自然科学基金重点项目(82130029)。

摘　　要：青光眼是由多种因素导致视神经损害、形成特征性视盘盘沿变窄及视野损害的疾病。青光眼神经损伤不仅累及视网膜节细胞,还涉及视觉通路和中枢神经系统的广泛性神经退行性病变。青光眼与其他中枢神经疾病有相似的病理变化,如脱髓鞘改变参与青光眼神经损伤的病理过程。因此,研究脱髓鞘发生机制和髓鞘再生功能,寻找促进髓鞘形成和髓鞘再生方法对从神经保护策略治疗青光眼具有重要意义。Glaucoma is a disease characterized by narrowing of the optic disc edge and visual field damage caused by various factors leading to optic nerve damage.Glaucoma nerve damage not only affects retinal ganglion cells,but also involves extensive neurodegenerative changes in the visual pathway and central nervous system.Glaucoma has similar pathological changes to other central nervous system diseases such as multiple sclerosis,and demyelination changes are involved in the pathological process of glaucoma nerve damage.Therefore,studying the mechanism of demyelination and remyelination function,promoting myelin formation and remyelination,and finding new treatment pathways for glaucoma from the perspective of neuroprotective strategies are of great significance.

关 键 词：青光眼 脱髓鞘 神经轴突 神经变性 髓鞘重建 

分 类 号：R775[医药卫生—眼科]