Utilizing lemon peel extract and its nano-emulsion to control aflatoxin toxicity in rats  

作　　者：Bassem A.Sabry Ahmed Noah Badr Kawkab A.Ahmed Marwa A.Desoukey Dina Mostafa Mohammed 

机构地区：[1]Department of Food Toxicology and Contaminants,National Research Centre,Dokki,Cairo,12622,Egypt [2]Pathology Department,Faculty of Veterinary Medicine,Cairo University,Giza,12211,Egypt [3]Department of Nutrition and Food Science,National Research Centre,Dokki,Cairo,12622,Egypt

出　　处：《Food Bioscience》2022年第6期1324-1333,共10页食品生物科学（英文）

摘　　要：The lemon peel is a flavonoid-hefty source and also has bioactive constituents,such as polyphenols.This research was performed to assess the potential of lemon peel essential oil and its nano-emulsion as a fruit waste in protecting against aflatoxin B1-induced toxicity in experimental animals.Thirty-six male Sprague-Dawley rats were administered a daily dosage of aflatoxin(80μg/kg b.w)treated with lemon peel essential oil and its nano-emulsion(100 mg/kg).All nutritional parameters,biochemical parameters,and histopathological examinations were evaluated.The results revealed severe toxicity and carcinogenicity of AFB1 established by elevation of TNF-αand IL-6 and pathogenic elevation in kidney and liver enzymes manifested by significant elevation of creatinine,urea,uric acid,AST,ALT,and ALP to 0.98,79.4,3.2,57.6,38,and 98.14,respectively.All these biochemical changes were confirmed by histopathological examination.All these harmful changes were amended by the use of lemon peel essential oil and its nano-emulsion,which led to the conclusion that lemon peel essential oil and its nano-emulsion as a fruit waste could be a promising source for the immune-enhancing drug that could protect against aflatoxin ingestion.

关 键 词：Lemon peel oil Bioactive compounds NANO-EMULSION AFLATOXIN Biochemical parameters TOXICITY 

分 类 号：TS201.4[轻工技术与工程—食品科学]