Agastache rugosa inhibits LPS-induced by RAW264.7 cellular inflammation and ameliorates oesophageal tissue damage from acute reflux esophagitis in rats  

作　　者：Li Nan Hyeon-Hwa Nam Byung-Kil Choo 

机构地区：[1]Agricultural College,Yanbian University,Yanji City,Jilin Province,People's Republic of China [2]Herbal Medicine Resources Research Center,Korea Institute of Oriental Medicine,Naju-si,Jeollanam-do,Republic of Korea [3]Department of Crop Science and Biotechnology,Chonbuk National University,Jeonju,Republic of Korea

出　　处：《Food Bioscience》2022年第6期1941-1948,共8页食品生物科学（英文）

基　　金：funded by“Cooperative Research Program for Agriculture Science&Technology Development(Project No.PJ0142272021)”Rural Development Administration,Republic of Korea;Also,this research was funded by Yanbian University Ph.D.Start-up Fund(Project No.602021037),China.

摘　　要：Agastache rugosa is a kind of herbal plant with good biological activity,which is used for both medicine and food.It is mainly used for the treatment of gastritis,heat stroke and other diseases.Reflux esophagitis is an inflammatory disease with an increasing incidence and a younger age group of patients,which seriously affects the quality of life of patients.In this study,the anti-inflammatory effect of ethanol extract of Agastache rugosa at the cellular level and the protective effect on exophages injury in rats with acute reflux esophagitis were determined.The results showed that the ethanol extract of Agastache rugosa reduced the expression of cytokines and effectively inhibited the cellular inflammation regulated by NF-κB.In addition,the injury state of rat exophages tissue was significantly improved and the expression of inflammatory factors in exophages tissue was inhibited.Thus,the ethanol extract of Agastache rugosa exhibits excellent anti-inflammatory activity and has the potential as a natural medicinal resource for the treatment of reflux esophagitis.

关 键 词：Agastache rugosa ANTI-INFLAMMATION NF-κB signalling pathway Reflux esophagitis 

分 类 号：TS201[轻工技术与工程—食品科学]