Fermented Psidium guajava leaves regulate the gut microbiota and improve metabolic alterations in diabetic mice  

作　　者：Zhenfeng Huang Zheng Fang Anping Wu Fei Shen Zhenqiang Wu 

机构地区：[1]School of Biology and Biological Engineering,South China University of Technology,Guangzhou,510006,PR China [2]Pan Asia(Jiangmen)Institute of Biological Engineering and Health,Jiangmen,529080,PR China

出　　处：《Food Bioscience》2023年第1期220-234,共15页食品生物科学（英文）

基　　金：Special Fund for Science and Technology of Guangdong Province,China(2019JK25203010);the Science and Technology Project of Guangdong Province,China(2017B020207003).

摘　　要：The phenolic extract from fermented Psidium guajava leaves(PFGL)helps to improve diabetes;however,its hypoglycemic and hypolipidemic mechanisms remain unclear.In this study,gut microbiota modulation and glucose-lipid metabolism was investigated.The results showed that dietary supplement of PFGL enriched in quercetin glucosides significantly improved serum glucose-lipid profiles as well as insulin resistance in diabetic mice.The gut microbiota of diabetic mice was modulated by PFGL(200 mg/kg),causing an abundance of Bacteroidetes,Prevotellaceae,and Alistipes and a reduced the presence of Firmicutes and Streptococcus.Increased levels of short-chain fatty acids(SCFA)activated G protein-coupled receptor signaling that induced peptide YY release to promote insulin secretion.Diabetes-induced serum metabolite disorders that are involved in glycerophospholipid metabolism and tryptophan metabolism were restored by PFGL.The protein expression of metabolic enzymes including phospho-adenosine 5’-monophosphate-activated protein kinase,fatty acid synthase,acyl-coenzyme A oxidase,and diacylglycerol aeyltransferase 2 were also regulated to promote glucoselipid metabolism.In particular,gut microbiota enriched with Alistipes genera and SCFA metabolic regulation were closely correlated with diabetes-related indicators.These findings provide a theoretical support for the development and application of PFGL for the treatment of diabetes.

关 键 词：Fermented Psidium guajava leaves Phenolic extract Gut microbiota Host metabolism HYPOGLYCEMIC HYPOLIPIDEMIC 

分 类 号：R587.1[医药卫生—内分泌]