Sumc(Rhus coriaria L.)fruit ameliorates paracetamol-induced hepatotoxicity  

作　　者：Tamam El-Elimat Bayan K.Al-Tal Nour A.Al-Sawalha Mohammad Alsaggar Shreen D.Nusair Reema Al-Qiam Ahmed H.Al Sharie Feras El Hajji Lama Hamadneh 

机构地区：[1]Faculty of Pharmacy,Jordan University of Science and Technology,Irbid,Jordan [2]Faculty of Medicine,Jordan University of Science and Technology,Irbid,Jordan [3]Faculty of Pharmacy,the Applied Science Private University,Amman,Jordan [4]Faculty of Pharmacy,Al-Zaytoonah University of Jordan,Amman,Jordan

出　　处：《Food Bioscience》2023年第2期1268-1276,共9页食品生物科学（英文）

基　　金：This research was supported by the Deanship of Research,Jordan University of Science and Technology,Irbid,Jordan(Grant No.355/2020).

摘　　要：Sumac[Rhus coriaria L.(Anacardiaceae)]is a widely used spice in the Middle East.In this study,the hepatoprotective effects of sumac fruit were evaluated using a rat model of paracetamol-induced liver injury.The experimental design relies on the pretreatment of rats with intraperitoneal sumac extract followed by a toxic dose of paracetamol.Tissue alterations,serum levels of oxidative stress markers,as well as gene expression of immunomarkers were evaluated.Rats pre-treated with sumac displayed attenuated signs of toxicity.Upon paracetamol intoxication,sumac-pretreated animals showed a minimal increase in liver enzyme levels.In parallel,serum albumin and total protein levels were close to normal.Moreover,pretreated sumac animals had preserved hepatocyte morphology,whereas unprotected animals had necrotic deformations.Importantly,these effects were dose-dependent and comparable to the silymarin-treated positive control group.In conclusion,sumac extract offers a potential hepatoprotective regimen against xenobiotic-induced hepatotoxicity and for oxidative stress management.

关 键 词：Rhus coriaria ANACARDIACEAE Sumac Paracetamol-induced liver injury Oxidative stress HEPATOTOXICITY SILYMARIN 

分 类 号：TS201[轻工技术与工程—食品科学]