Recent advances in copper homeostasis-involved tumor theranostics  

作　　者：Xinghua Ren Xinyi Luo Fuchang Wang Long Wan Xiaofan Wang Jinya Xiong Mengwei Ye Shiqiao Rui Zhu Liu Siling Wang Qinfu Zhao 

机构地区：[1]Department of Pharmaceutics,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China [2]Wuya College of innovation,Shenyang Pharmaceutical University,Shenyang 110016,China [3]Department of Pharmacy,The First Hospital of China Medical University,Shenyang 110001,China [4]Department of Pharmacy,The Fourth Affiliated Hospital of China Medical University,Shenyang 110001,China [5]School of Pharmacy,China Medical University,Shenyang 110122,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2024年第5期54-87,共34页亚洲药物制剂科学（英文）

基　　金：Grant from Liaoning Provincal National Nature Science Foundation of China(No.2023-MS-202)is greatly acknowledged.

摘　　要：As the third essential trace element in the human body,copper plays a crucial role in various physiological processes,which lays the foundation for its broad applications in cancer treatments.The overview of copper,including pharmacokinetics,signaling pathways,and homeostasis dysregulation,is hereby discussed.Additionally,cuproptosis,as a newly proposed cell death mechanism associated with copper accumulation,is analyzed and further developed for efficient cancer treatment.Different forms of Cu-based nanoparticles and their advantages,aswell as limiting factors,are introduced.Moreover,the unique characteristics of Cu-based nanoparticles give rise to their applications in various imaging modalities.In addition,Cu-based nanomaterials are featured by their excellent photothermal property and ROS-associated tumor-killing potential,which are widely explored in diverse cancer therapies and combined therapies.Reducing the concentration of Cu^(2+)/Cu^(+)is another cancer-killing method,and chelators can meet this need.More importantly,challenges and future prospects are identified for further research.

关 键 词：Copper homeostasis Tumor theranostics Cu-based nanoparticles Cuproptosis CHELATORS 

分 类 号：R730.5[医药卫生—肿瘤]