Extracellular vesicle-functionalized bioactive scaffolds for bone regeneration  

作　　者：Taozhao Yu Irene Shuping Zhao Hongguang Pan Jianhua Yang Huanan Wang Yongqiang Deng Yang Zhang 

机构地区：[1]School of Dentistry,Shenzhen University Medical School,Shenzhen 518015,China [2]School of Biomedical Engineering,Shenzhen University Medical School,Shenzhen 518015,China [3]Department of Otolaryngology,Shenzhen Children Hospital,Shenzhen 518034,China [4]Longgang District People’s Hospital of Shenzhen&The Second Affiliated Hospital,The Chinese University of Hong Kong,Shenzhen 518172,China [5]Key State Laboratory of Fine Chemicals,School of Bioengineering,Dalian University of Technology,Dalian 116024,China [6]Department of Stomatology,Shenzhen University General Hospital,Shenzhen University,Shenzhen 518055,China [7]Institute of Stomatological Research,Shenzhen University,Shenzhen 518055,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2024年第5期88-103,共16页亚洲药物制剂科学（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(No.31900966&82001105);the Guangdong Provincial Basic and Applied Basic Research(No.2019A1515110415);Shenzhen Medical Academy of Research and Translation(A2303069);the Shenzhen Basic Research Program General Project(JCYJ20220530162206012);Medicine Plus Project of Shenzhen University.

摘　　要：The clinical need for effective bone regeneration in compromised conditions continues to drive demand for innovative solutions.Among emerging strategies,extracellular vesicles(EVs)have shown promise as an acellular approach for bone regeneration.However,their efficacy is hindered by rapid sequestration and clearance when administered via bolus injection.To address this challenge,EV-functionalized scaffolds have recently been proposed as an alternative delivery strategy to enhance EV retention and subsequent healing efficacy.This review aims to consolidate recent advancements in the development of EV-functionalized scaffolds for augmenting bone regeneration.It explores various sources of EVs and different strategies for integrating them into biomaterials.Furthermore,the mechanisms underlying their therapeutic effects in bone regeneration are elucidated.Current limitations in clinical translation and perspectives on the design of more efficient EVs for improved therapeutic efficacy are also presented.Overall,this review can provide inspiration for the development of novel EV-assisted grafts with superior bone regeneration potential.

关 键 词：Extracellular vesicles EXOSOMES BIOMATERIALS Local delivery Bone regeneration 

分 类 号：R318.08[医药卫生—生物医学工程]