Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury  

作　　者：Weihang Zhou Xinchi Jiang Jianqing Gao 

机构地区：[1]State Key Laboratory of Advanced Drug Delivery and Release Systems,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China [2]Department of Pharmacy,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China [3]Hangzhou Institute of Innovative Medicine,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2024年第6期1-20,共20页亚洲药物制剂科学（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(U22A20383,82003668);the Natural Science Foundation of Zhejiang Province(LD22H300002,LQ21H300002);Ningbo Technology Innovation 2025 Major Special Project(2022Z150).

摘　　要：Ischemia/reperfusion(I/R)injury ismarked by the restriction and subsequent restoration of blood supply to an organ.This process can exacerbate the initial tissue damage,leading to further disorders,disability,and even death.Extracellular vesicles(EVs)are crucial in cell communication by releasing cargo that regulates the physiological state of recipient cells.The development of EVs presents a novel avenue for delivering therapeutic agents in I/R therapy.The therapeutic potential of EVs derived from stem cells,endothelial cells,and plasma in I/R injury has been actively investigated.Therefore,this review aims to provide an overview of the pathological process of I/R injury and the biophysical properties of EVs.We noted that EVs serve as nontoxic,flexible,and multifunctional carriers for delivering therapeutic agents capable of intervening in I/R injury progression.The therapeutic efficacy of EVs can be enhanced through various engineering strategies.Improving the tropism of EVs via surface modification and modulating their contents via preconditioning are widely investigated in preclinical studies.Finally,we summarize the challenges in the production and delivery of EV-based therapy in I/R injury and discuss how it can advance.This review will encourage further exploration in developing efficient EV-based delivery systems for I/R treatment.

关 键 词：Extracellular vesicles Extracellular vesicle engineering Ischemia/reperfusion injury NANOCARRIER Drug delivery 

分 类 号：R363[医药卫生—病理学]