基于Hisense CAS的儿童肝脏肿瘤实时交互仿真形变模型的构建  

Establishment and clinical significance of individualized interactive virtual simulation model of liver tumors in children

作　　者：张警丽 修文丽 王静淼 陈鑫[1] 张桓瑜 杨霞 王菲菲 王凤娇 夏楠 郝希伟[1] 贾世宇 董蒨[1,2] ZHANG Jingli;XIU Wenli;WANG Jingmiao;CHEN Xin;ZHANG Huanyu;YANG Xia;WANG Feifei;WANG Fengjiao;XIA Nan;HAO Xiwei;JIA Shiyu;DONG Qian(Department of Pediatric Surgery,the Affiliated Hospital of Qingdao University,Qingdao,Shandong 266003,China;Shandong Key Laboratory of Digital Medicine and Computer Assisted Surgery,Qingdao,Shandong 266003,China;College of Computer Science and Technology,Qingdao University,Qingdao,Shandong 266071,China)

机构地区：[1]青岛大学附属医院小儿外科,山东青岛266003 [2]山东省数字医学与计算机辅助手术重点实验室,山东青岛266003 [3]青岛大学计算机科学技术学院,山东青岛266071

出　　处：《肝胆胰外科杂志》2024年第12期716-722,728,共8页Journal of Hepatopancreatobiliary Surgery

基　　金：国家自然科学基金项目(82293660,82293665)。

摘　　要：目的构建个体化肝脏肿瘤形变模型,并验证形变模型与器械交互时的形变仿真效果,以评估其在肝脏肿瘤切除手术中的可行性。方法选取6例接受手术切除的肝脏肿瘤患儿术前增强CT数据,基于Hisense计算机辅助手术系统生成个体化肝脏肿瘤三维面模型,使用本团队之前提出的形变模型构建方法,运用C++编程语言,将个体化三维模型的面模型数据转换为个体化体模型。采用共旋线性有限元算法对体模型数据进行求解,施加肝脏软组织生物力学特性,创建个体化的肝脏肿瘤形变模型。在实验室仿真环境中进行肝脏变形实验,验证模型变形的真实性和稳定性。邀请13名小儿外科医师对模型进行测试与评估,收集其主观反馈并进行统计。结果成功构建6例个体化患儿肝脏肿瘤的三维面模型,获得具有高体素密度和高分辨率的个体化的体模型,并实现肝脏软组织生物力学特性的施加,成功创建个体化的肝脏肿瘤形变仿真模型。仿真模型的任何部位均可与虚拟手术器械进行交互,按压和牵拉肝脏变形过程中,仿真帧率在150 Hz左右,达到了视觉连续性所需的更新频率要求。满意度量表平均得分4.33分,大多数参与者对形变模型的颜色、对比度、辅助效果和实用性表示满意,认可其真实性和价值。结论本研究创建的形变模型能够满足肝脏肿瘤虚拟手术的真实性和稳定性要求,可将此模型运用到研发个体化虚拟腹腔镜手术仿真系统,未来精准地指导腹腔镜下肝脏肿瘤外科手术操作。Objective To develop an individualized liver tumor deformation model and to assess the effectiveness of the deformation simulation when interacting with the device,thereby evaluating its feasibility for liver tumor resection.Methods Preoperative enhanced CT data from 6 children with liver tumors scheduled for surgical resection were selected.An individualized 3D surface model of the liver tumors was generated using the Hisense computer-assisted surgery system.The morphable model construction method previously proposed by our team was employed to convert the surface model data of the individualized 3D model into an individualized volume model,utilizing the C++programming language.The corotational linear finite element algorithm was employed to analyze the volume model data,while the biomechanical properties of the liver soft tissue were utilized to develop an individualized model for liver tumor deformation.Subsequent liver deformation experiments were conducted in a laboratory simulation environment to validate the accuracy and reliability of the model.Thirteen pediatric surgeons were invited to test and to evaluate the model,and their subjective feedbacks were collected and counted.Results Three-dimensional surface models of this 6 children’s liver tumors were successfully constructed,resulting in individualized volume models characterized by high voxel density and resolution.The biomechanical properties of the liver’s soft tissue were applied,leading to the successful creation of individualized deformation simulation models for the liver tumors.The simulation model allowed for interaction with the virtual surgical instrument,achieving an average frame rate of approximately 150 Hz during the processes of pressing and pulling the liver deformation.This performance met the update frequency requirements necessary for visual continuity.The average score on the scale satisfaltion was 4.33,indicating that most participants expressed satisfaction with the color,contrast,auxiliary effect,and practicality of the morp

关 键 词：肝切除术 手术仿真 软组织形变仿真 儿童肝脏肿瘤 

分 类 号：R735.7[医药卫生—肿瘤]