Curcumin alleviates lipid deposition in hepatocytes through miR-3666/AMPK axis regulation  

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作  者:Hengju Ge Jiaxin Li Yang Xu Jiahong Xie Naymul Karim Fujie Yan Jianling Mo Wei Chen 

机构地区:[1]Department of Traditional Chinese Medicine,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou,310016,China [2]Department of Food Science and Nutrition,College of Biosystems Engineering and Food Science,Zhejiang University,Hangzhou,310058,China

出  处:《Food Bioscience》2023年第3期637-644,共8页食品生物科学(英文)

基  金:supported by grants from Zhejiang Provincial Key R&D Program of China(2021C02018);National Natural Science Foundation of China(32172192).

摘  要:Curcumin(CUR),the main compound extracted from Curcuma longa,has various biological actions,including hepatoprotective,anti-infective,anti-inflammatory,antioxidant,and neurotrophic properties.But it has not yet been clarified how CUR affects the accumulation of fatty in hepatic cells.Our study uncovered that CUR decreased the lipid deposition in free fat acids(FFAs)-treated hepatocytes,which could be blocked by Compound C(an AMPK inhibitor).This result suggests that protective effect was associated with the AMPK pathway activation.MiR-3666 directly targets the AMPK gene,and overexpression of miR-3666 greatly weakens the hypolipidemic effect of CUR.Our results showed that CUR reduced FFAs-induced lipid deposition by targeting miR-3666.This boosted AMPK phosphorylation and inhibited its downstream targets,including ACC and SREBP1.These findings together confirm that CUR-mediated inhibition of miR-3666 to activate the AMPK pathway is a potential alternative for alleviation of hepatic lipid deposition.

关 键 词:CURCUMIN Lipid deposition MiR-3666 AMPK pathways HEPATOPROTECTION 

分 类 号:TS201[轻工技术与工程—食品科学]

 

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