Bacterial community mapping of the AIA mouse gastrointestinal tract under dietary intervention with skipjack tuna(Katsuwonus pelamis)elastin peptides  

作　　者：Qiaoli Wu Bing Liu Rongxian Yu Xiaoling Sun Ziyan Wang Jun Zhou Chenyang Lu Haitao Wan Jing Zhang Jiaojiao Han Xiurong Su 

机构地区：[1]State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products,Ningbo University,Ningbo,China [2]School of Marine Science,Ningbo University,Ningbo,China [3]Key Laboratory of Aquaculture Biotechnology(Ningbo University)Ministry of Education,Ningbo University,Ningbo,China [4]Vigor Health Products Co.,Ltd,Shenzhen,518118,China [5]Faculty of Food Science,Zhejiang Pharmaceutical College,Ningbo,China

出　　处：《Food Bioscience》2023年第3期1479-1488,共10页食品生物科学（英文）

基　　金：sponsored by the National Key R&D Program of China(2018YFD0901102);the Fund of State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products(ZS20190105);the Natural Foundation of Zhejiang Province(LQ22D060002);the Cooperative Project of Vigour Health Products Co.,Ltd,Shenzhen;the K.C.Wong Magna Fund of Ningbo University.

摘　　要：Background:Our previous study demonstrated that a dietary intervention with skipjack tuna(Katsuwonus pelamis)elastin peptides alleviated adjuvant-induced arthritis(AIA)and affected the gut microbiota of AIA mice.How-ever,whether the faecal microbiota serves as a surrogate to reflect the dynamics of the gut microbiota has not been determined.Methods:Using 16 S rRNA sequencing technology,the present study investigated the microbiota in three seg-ments(stomach,colon and caecum)of mice to comprehensively define microbial dysregulation and regulation related to rheumatoid arthritis(RA).Results:The results showed that the composition and distribution of the microbiota in the stomach,colon and caecum were significantly different depending on their intrinsic environment and their functions,and the colon possessed the richest and most diverse microbiota structure.The gut microbiota of AIA mice showed ecological dysbiosis,and a dietary intervention with skipjack tuna elastin peptides improved this negative effect,partic-ularly the changes in the gastric microbiota,which were most obvious at RA onset and remission.Implication:The results not only indicate the spatial heterogeneity of the gut microbiota in terms of composition and distribution,but also indicate the potential of the application of elastin peptides for the alleviation of RA.

关 键 词：Mice with adjuvant-induced arthritis Skipjack tuna(Katsuwonus pelamis)elastin PEPTIDES Gastrointestinal tract Gut microbiota Faecal microbiota 

分 类 号：TS201.3[轻工技术与工程—食品科学]