Nanostructured lipid carrier as a strategy for encapsulation of formononetin and perilla seed oil:In vitro characterization and stability studies  

作　　者：Lijun Zheng Hongjia Xu Hanxin Zhang Caihong Shi Wei Zhou Xiangrong Zhang 

机构地区：[1]School of Functional Food and Wine,Shenyang Pharmaceutical University,103 Wenhua Road,Shenyang,110016,China [2]Survey of Hydrogeology,Engineering&Environmental Geology in Qinghai,No.4 Sujiahewan,Xining,810008,China [3]Key Laboratory of Hydrogeological and Geothermal Geological of Qinghai Province,No.4 Sujiahewan,Xining,810008,China

出　　处：《Food Bioscience》2023年第3期2340-2350,共11页食品生物科学（英文）

基　　金：supported by Livelihood Plan Project of Department of Science and Technology of Liaoning Province(2021JH2/10300069,2019-ZD-0845);Department of Education of Liaoning Province(LJKZ0918).

摘　　要：This study aims to characterize formononetin(FMN)and perilla seed oil(PSO)co-loaded nanostructured lipid carriers(NLC).FMN-PSO-NLC was prepared by melt-emulsification ultrasonic method.The average particle size of FMN-PSO-NLC was 117.5±3.7 nm,with PDI of 0.240±0.017 and zeta potential of-36.7±0.7 mV.Dif-ferential scanning calorimetry(DSC),X-ray diffractometry(XRD),and Fourier transform infrared spectroscopy(FTIR)studies revealed that the formation of FMN-PSO-NLC was accompanied by changes in crystallinity and intermolecular interactions.FMN-PSO-NLC dispersions possessed pseudoplastic flow from the rheological studies.FMN-PSO-NLC possessed sustained-release of FMN for 24 h.FMN-PSO-NLC was more easily digested than that of PSO in vitro digestion.The antioxidant activity and stability of FMN-PSO-NLC were significantly improved.This study provides a formulation design for improving the stability,antioxidant activity of FMN and delaying the oxidation of PSO.

关 键 词：Nanostructured lipid carrier FORMONONETIN Perilla seed oil Antioxidant activity In vitro gastrointestinal Digestion 

分 类 号：TS206.4[轻工技术与工程—食品科学]