pH-controlled release feature of chitosan assembled silica nanoparticles containing nano-formulated curcumin over in vitro gastric and physiological condition  

作　　者：Ozi Adi Saputra Wahyu Nur Safitriono Dyah Ellyawati Kusumaningtyas Maharani Amalia Febiana Fajar Rakhman Wibowo 

机构地区：[1]Sustainable Chemical Science and Technology,Taiwan International Graduate Program Academia Sinica,Taipei,11529,Taiwan [2]Institute of Chemistry,Academia Sinica,Taipei,11529,Taiwan [3]Department of Chemical Engineering,Collage of Engineering National Taiwan University,Taipei,10617,Taiwan [4]Master Program of Chemistry,Universitas Sebelas Maret,Surakarta,57126,Indonesia [5]Department of Chemistry,Faculty of Mathematic and Natural Science,Universitas Sebelas Maret,Surakarta,57126,Indonesia

出　　处：《Food Bioscience》2023年第3期2835-2846,共12页食品生物科学（英文）

基　　金：Directorate General of Higher Education,Ministry of Education,Culture,Research and Technology,Indonesia for funding this research through Program Kreativitas Mahasiswa(PKM)2021(No.1949/E2/KM.05.01/2021);partially supported by Universitas Sebelas Maret through Pene-litian Unggulan Terapan(PUT)2021 research scheme(No.260/UN27.22/HK.07.00/2021).

摘　　要：Low water solubility leading to poor bioavailability has an impact on the decreasing of curcumin uptake in the body,resulting in a deficiency of its medicinal benefits.This study aims to overcome the limitations of curcumin by formulating a nano-emulsion called curcumin emulsion(CE).Furthermore,in order to improve the physi-cochemical properties and drug release features,the CE was encapsulated within chitosan-assembled mesoporous silica nanoparticles(Chi@SiO_(2)@CE).This material was prepared using a one-pot method and was characterized by Attenuated-total reflectance(ATR-FTIR),Particle Size Analyzer(PSA),Thermogravimetric analysis(TGA),N_(2)adsorption-desorption,Scanning Electron Microscopy(SEM),and Transmission Electron Microscopy(TEM).Additionally,antioxidant activity and in vitro drug release were also conducted.The study demonstrated that CE has strong antioxidant activity(IC_(50)=14.14μM)compared to curcumin alone.Additionally,the Chi@SiO_(2)@CE exhibited pH-controlled release behavior,with less than 20%release of curcumin under an artificial gastric environment and 50%release under pH 7.4 conditions within 24 h.Therefore,this research suggest that Chi@SiO_(2)@CE material has potential as a pH-responsive drug delivery material.

关 键 词：ANTIOXIDANT BIOMATERIALS Drug delivery Mesoporous materials Nanoparticles 

分 类 号：TS201[轻工技术与工程—食品科学]