PM_(2.5)-Metabolic Syndrome Causal Association:A Mendelian Randomization Study  

作　　者：Fan Ding Ning Ma Shi Zhao Qingan Wang Zhanbing Ma Yuhong Zhang Yi Zhao Yu Zhao 

机构地区：[1]School of Public Health,Ningxia Medical University,Yinchuan 750004,Ningxia,China [2]NHC Key Laboratory of Metabolic Cardiovascular Diseases Research,Ningxia Medical University,Yinchuan 750004,Ningxia,China [3]Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control,Yinchuan Ningxia 750004,Ningxia,China [4]Centre for Health Systems and Policy Research,Chinese University of Hong Kong,Hong Kong 99907,China [5]CUHK Shenzhen Research Institute,Shenzhen 518000,Guangdong,China [6]School of Basic Medicine,Ningxia Medical University,Yinchuan 750001,Ningxia,China

出　　处：《Biomedical and Environmental Sciences》2024年第12期1421-1426,共6页生物医学与环境科学（英文版）

基　　金：funded by the National Natural Science Foundation of China[12061058];National Natural Science Foundation of Ningxia[2023AAC02033];and the Key Research and Development Plan Project of Ningxia[2021BEG02026].

摘　　要：Metabolic syndrome(MS)is a common metabolic disorder status and defined as a pathology characterized by abdominal obesity,insulin resistance,hypertension,and hyperlipidemia(atherosclerosis)status[1].Evidence suggests that the underlying etiology of MS is multifactorial and includes environmental factors,tobacco use,high alcohol consumption,dietary risks,and low physical activity.Thus,a deeper understanding of MS and its risk factors will be beneficial for mitigating health damage and improving the quality of life in high-risk subpopulations.PM_(2.5)is an important environmental pollutant,poses a serious threat to human health,and is associated with various health problems.Several epidemiological studies have shown that exposure to PM_(2.5)may influence the development of diabetes[2],cardiovascular disease,obesity,and MS.Existing evidence also suggests that the components of MS are sensitive to environmental pollutants,especially PM_(2.5).However,most of them were observational studies or literature analyses based on epidemiology。

关 键 词：METABOLIC EPIDEMIOLOGY OBESITY 

分 类 号：R589[医药卫生—内分泌] R12[医药卫生—内科学]