血清miR⁃21、MMP⁃2及EGFR在肺癌靶向治疗中的检测价值  

The monitoring value of serum miR⁃21,MMP⁃2 and EGFR in targeted therapy for lung cancer

作　　者：刘长江 刘爽 周能 李淋淋 杨文平 LIU Changjiang;LIU Shuang;ZHOU Neng;LI Linlin;YANG Wenping(Department of Respiratory and Critical Care Medicine,the Affiliated People's Hospital of Shandong First Medical University,Jinan People's Hospital,Laiwu,Shandong,China,271100)

机构地区：[1]山东第一医科大学附属人民医院(济南市人民医院)呼吸与危重症医学科,山东莱芜271100

出　　处：《分子诊断与治疗杂志》2024年第12期2228-2231,2235,共5页Journal of Molecular Diagnostics and Therapy

基　　金：山东省自然科学基金项目(2019872)。

摘　　要：目的分析血清微小RNA⁃21(miR⁃21)、基质金属蛋白酶⁃2(MMP⁃2)及表皮生长因子(EGFR)在肺癌靶向治疗中的检测价值。方法选取2021年1月至2023年12月山东第一医科大学附属人民医院收治的经病理确诊的110例NSCLC患者为研究对象。对比NSCLC患者治疗前、治疗后miR⁃21、MMP⁃2、EGFR水平;统计所有患者靶向治疗结果;分析影响NSCLC患者靶向治疗疗效的相关因素;计算miR⁃21、MMP⁃2、EGFR单独及联合预测NSCLC患者靶向治疗疗效的价值。结果NSCLC患者治疗后miR⁃21、MMP⁃2水平以及EGFR阳性率均低于治疗前,差异有统计学意义(P<0.05)。110例NSCLC患者经靶向治疗后,治疗显效21(19.09%),治疗有效35(31.82%),治疗无效54(49.09%)。将治疗显效与有效纳为有效组(n=56),将治疗无效纳入为无效组(n=54)。有效组miR⁃21、MMP⁃2水平低于无效组,EGFR突变阳性率高于无效组,差异有统计学意义(P<0.05)。二元Logistic回归分析结果显示:miR⁃21、MMP⁃2水平升高、EGFR突变阳性率降低均为影响NSCLC患者靶向治疗疗效的影响因素(P<0.05)。miR⁃21、MMP⁃2、EGFR联合预测NSCLC患者靶向治疗疗效的AUC为0.896,敏感度、特异度分别为93.10%、88.46%,高于三指标单独检测(P<0.05)。结论miR⁃21、MMP⁃2、EGFR联合检查对于NSCLC患者靶向治疗疗效具有重要的参考价值,可为制定临床治疗方案提供一定依据。Objective To Analyze the detection value of serum microRNA⁃21(miR⁃21),matrix metalloproteinase⁃2(MMP⁃2),and epidermal growth factor receptor(EGFR)in targeted therapy for lung can⁃cer.Methods A total of 110 patients diagnosed with NSCLC by pathology at The Affiliated People's Hospital of Shandong First Medical University from January 2021 to December 2023 were selected as the subjects for this research.The levels of miR⁃21,MMP⁃2,and EGFR in NSCLC patients before and after treatment were compared.The treatment outcomes of all patients were recorded in order to analyze the factors that influence the effectiveness targeted therapy in patients with NSCLC.The predictive value of miR⁃21,MMP⁃2,EGFR alone,and in combination for determining the efficacy of targeted therapy in NSCLC patients was also calcu⁃lated.Results The levels of miR⁃21,MMP⁃2 and the positive rate of EGFR in NSCLC patients after treat⁃ment were lower than those before treatment,and the difference was statistically significant(P<0.05).After targeted therapy,21(19.09%)were markedly effective,35(31.82%)were effective,and 54(49.09%)were ineffective.The markedly effective and effective treatment were included in the effective group(n=56),while the ineffective treatments were included in the ineffective group(n=54).The levels of miR⁃21 and MMP⁃2 in the effective group were lower than those in the ineffective group,and the positive rate of EGFR mutation was higher than that in the ineffective group,and the difference was statistically significant(P<0.05).The results of binary logistic regression analysis showed that the increase in miR⁃21 and MMP⁃2 levels and the decrease in EGFR mutation positive rate were all influencing factors affecting the efficacy of targeted therapy in NSCLC patients(P<0.05).The AUC of miR⁃21,MMP⁃2 and EGFR combined to predict the efficacy of targeted therapy in NSCLC patients was 0.896,with a sensitivity and specificity of 93.10%and 88.46%,respectively,which were higher than the three indicators al

关 键 词：miR⁃21 MMP⁃2 EGFR 肺癌靶向治疗 

分 类 号：R734.2[医药卫生—肿瘤]