The multiple roles of interferon regulatory factor family in health and disease  

作　　者：Lian Wang Yanghui Zhu Nan Zhang Yali Xian Yu Tang Jing Ye Fekrazad Reza Gu He Xiang Wen Xian Jiang 

机构地区：[1]Department of Dermatology&Venerology,West China Hospital,Sichuan University,Chengdu 610041,China [2]Laboratory of Dermatology,Clinical Institute of Inflammation and Immunology,Frontiers Science Center for Disease-related Molecular Network,State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,China [3]State Key Laboratory of Southwestern Chinese Medicine Resources,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China [4]Radiation Sciences Research Center,Laser Research Center in Medical Sciences,AJA University of Medical Sciences,Tehran,Iran [5]International Network for Photo Medicine and Photo Dynamic Therapy(INPMPDT),Universal Scientific Education and Research Network(USERN),Tehran,Iran

出　　处：《Signal Transduction and Targeted Therapy》2024年第11期4935-4982,共48页信号转导与靶向治疗（英文）

基　　金：supported by the Fundamental Research Funds for the National Natural Science Foundation of China(Nos.82103757,82273559,82104373 and 82304063);Sichuan Natural Science Foundation Project(2023NSFSC1554 and 24NSFSC5087).

摘　　要：Interferon Regulatory Factors(IRFs),a family of transcription factors,profoundly influence the immune system,impacting both physiological and pathological processes.This review explores the diverse functions of nine mammalian IRF members,each featuring conserved domains essential for interactions with other transcription factors and cofactors.These interactions allow IRFs to modulate a broad spectrum of physiological processes,encompassing host defense,immune response,and cell development.Conversely,their pivotal role in immune regulation implicates them in the pathophysiology of various diseases,such as infectious diseases,autoimmune disorders,metabolic diseases,and cancers.In this context,IRFs display a dichotomous nature,functioning as both tumor suppressors and promoters,contingent upon the specific disease milieu.Post-translational modifications of IRFs,including phosphorylation and ubiquitination,play a crucial role in modulating their function,stability,and activation.As prospective biomarkers and therapeutic targets,IRFs present promising opportunities for disease intervention.Further research is needed to elucidate the precise mechanisms governing IRF regulation,potentially pioneering innovative therapeutic strategies,particularly in cancer treatment,where the equilibrium of IRF activities is of paramount importance.

关 键 词：DISEASES PRECISE PHYSIOLOGICAL 

分 类 号：R73[医药卫生—肿瘤]