A morphologically transformable hypoxia-induced radical anion for tumor-specific photothermal therapy  

作　　者：Hongyu Wang Dengyuan Hao Qihang Wu Tingting Sun Zhigang Xie 

机构地区：[1]State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [2]School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第12期5407-5417,共11页药学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(52003267 and 51973214);the Natural Science Foundation of Jilin Province(YDZJ202101ZYTS027,China).

摘　　要：Tumor microenvironment activatable therapeutic agents and their effective tumor accumula-tion are significant for selective tumor treatment.Herein,we provide an unadulterated nanomaterial combining the above advantages.We synthesize a perylene diimide(PDI)molecule substituted by glu-tamic acid(Glu),which can self-assemble into small spherical nanoparticles(PDI-SG)in aqueous solu-tion.PDI-SG can not only be transformed into nanofibers at low pH conditions but also be reduced to PDI radical anion(PDI^(·-)),which exhibits strong near-infrared absorption and excellent photothermal perfor-mance.More importantly,PDI-SG can also be reduced to PDI^(·-)in hypoxic tumors to ablate the tumors and minimize the damage to normal tissues.The morphological transformation from small nanoparticles to nanofibers makes for better tumor accumulation and retention.This work sheds light on the design of tumor microenvironment activatable therapeutics with precise structures for high-performance tumor therapy.

关 键 词：Perylene diimide Morphological transformation Radical anion HYPOXIA TUMOR-SPECIFIC Photothermal therapy NANOFIBER Amino acid 

分 类 号：R730.5[医药卫生—肿瘤]