Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy  

作　　者：Jiechen Liu Xiaoguang Li Ruiyang Xia Yuqi Wang Fenghe Zhang Yongzhi Pang Qing Li 

机构地区：[1]School and Hospital of Stomatology,Cheeloo College of Medicine,Shandong University,Ji’nan 250012,China [2]China&Shandong Key Laboratory of Oral Tissue Regeneration,Ji’nan 250012,China [3]China&Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration,Ji’nan 250012,China [4]Department of Stomatology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Ji’nan 250021,China [5]Department of Oral and Maxillofacial Surgery,Jinan Stomatology Hospital,Ji’nan 250001,China

出　　处：《Chinese Chemical Letters》2024年第12期239-244,共6页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81802709);the Shandong Provincial Natural Science Foundation,China(Nos.ZR2023MH230,ZR2023MH096);the Shandong Provincial Postdoctoral Innovative Talents Funded Scheme;Plan of Young Scholars of Shandong University。

摘　　要：Patients with oral squamous cell carcinoma(OSCC)encounter challenges in achieving efficient antitumor immunity,primarily due to the inherent pathophysiological characteristics of solid tumors affecting drug accumulation and penetration.Insufficient T-cells and immune escape induced by tumor-associated macrophages(TAMs)further exacerbate these issues.This study utilized M1 macrophage membranemodified spatial dimension conversion drug delivery systems(SDDDSs)and introduced photosensitizers chlorophyll Pyro and the immune agonist R848.This innovative approach enhanced tumor targeting and accumulation by transforming stimulus-responsive size-reductive SDDDSs into smaller-sized i RGD-Pyro and R848 within the extracellular tumor microenvironment(TME).This facilitated effective drug penetration into deep tumor regions and cellular uptake.The synergistic treatment strategy for OSCC,combining photodynamic therapy(PDT)and tumor immunotherapy,induced tumor cell apoptosis,triggered immunogenic cell death(ICD),polarized TAMs towards the M1 phenotype,promoted sufficient T-cell infiltration,and resulted in significant therapeutic outcomes.This approach offers a promising avenue for future OSCC therapeutic interventions.

关 键 词：OSCC IMMUNOTHERAPY PDT SDDDSs Downsize 

分 类 号：R739.8[医药卫生—肿瘤]