微生物发酵法生产L-丙氨酸的研究进展  

Progress on Microbial Fermentation Production of L-alanine

作　　者：聂玉朋 任雪冰 韩延雷 田延军 NIE Yupeng;REN Xuebing;HAN Yanlei;TIAN Yanjun(School of Science Health and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Qilu University of Technology(Shandong Academy of Sciences),Shandong Food Ferment Industry Research&Design Institute,Jinan 250000,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]齐鲁工业大学(山东省科学院),山东省食品发酵工业研究设计院,山东济南250013

出　　处：《工业微生物》2024年第6期64-68,共5页Industrial Microbiology

摘　　要：L-丙氨酸作为一种天然氨基酸,被广泛应用于食品、医药和个人护理等领域。目前,L-丙氨酸的生产主要依赖于可再生碳源的经济、绿色且可持续的微生物发酵。为提高L-丙氨酸的发酵产量,现有研究尝试了多种代谢工程策略,为降低L-丙氨酸的生产成本提供了有效途径与借鉴。基于此,文章主要对高产L-丙氨酸菌株的代谢工程改造策略和发酵关键技术进行综述,以期为后续高产L-丙氨酸微生物细胞工厂的构建提供参考。L-alanine,one of the natural amino acids,is widely used in food,pharmaceutical and personal care applications.Currently,the production of L-alanine relies on economical,green and sustainable microbial fermentation using renewable carbon sources.In order to increase the fermentation titer of L-alanine,various metabolic engineering strategies have been employed to provide effective ways to reduce the production cost of L-alanine.This paper mainly reviews the metabolic engineering modification strategies and fermentation key technologies of high-titer L-alanine strains,with a view to providing references for the construction of subsequent high-titer L-alanine microbial cell factories.

关 键 词：L-丙氨酸 微生物发酵 代谢工程 

分 类 号：TQ922[轻工技术与工程—发酵工程]