孟德尔随机化在糖尿病视网膜病变研究中的应用与展望  

Application and prospects of Mendelian randomization in diabetic retinopathy

作　　者：李筱荣 任邵杰 LI Xiaorong;REN Shaojie(Tianjin Key Laboratory of Retinal Functions and Diseases,Tianjin Branch of National Clinical Research Center for Ocular Disease,Eye Institute and School of Optometry,Tianjin Medical University Eye Hospital,Tianjin 300384,China)

机构地区：[1]天津医科大学眼科医院、眼视光学院、眼科研究所国家眼耳鼻喉疾病临床医学研究中心天津市分中心天津市视网膜功能与疾病重点实验室,天津市300384

出　　处：《眼科新进展》2025年第1期1-4,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金面上项目(编号:82171085)。

摘　　要：糖尿病视网膜病变(DR)是糖尿病患者常见的眼部并发症,也是导致成人失明的主要原因之一。由于DR的复杂病理机制及其与其他代谢紊乱的紧密联系,探索其病因并开发有效的预防和治疗手段成为公共卫生领域的紧迫需求。孟德尔随机化作为一种新兴的因果推断方法,通过利用遗传变异来推断暴露与疾病之间的因果关系,能够有效控制混杂因素和逆因果关系的影响。本述评旨在介绍孟德尔随机化及其在DR病因探索中的应用和研究进展,同时分析当前研究的局限性与未来发展方向。Diabetic retinopathy(DR)is a common ocular complication in patients with diabetes and one of the leading causes of blindness in adults.Due to the complex pathological mechanism of DR and its close relationship with other metabolic disorders,it has become an urgent need in the field of public health to explore its etiology and develop effective prevention and treatment methods.As a new causal inference method,Mendelian randomization(MR)can effectively control the influence of confounding factors and inverse causality by using genetic variations to infer the causal relationship between exposure and diseases.The purpose of this paper is to introduce the application and research progress of MR in the investigation of the etiology of DR and analyze the limitations of current research and the future development direction.

关 键 词：糖尿病视网膜病变 孟德尔随机化 单核苷酸多态性 因果推断 

分 类 号：R774.1[医药卫生—眼科]